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Control of cell proliferation by memories of mitosis.

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  • معلومة اضافية
    • المصدر:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
    • بيانات النشر:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • الموضوع:
      Cell Proliferation*/genetics ; Mitosis*/drug effects ; Mitosis*/genetics ; Neoplasms*/genetics ; Neoplasms*/pathology ; Ubiquitin Thiolesterase*/genetics ; Ubiquitin Thiolesterase*/metabolism ; Tumor Suppressor p53-Binding Protein 1*/genetics ; Tumor Suppressor p53-Binding Protein 1*/metabolism; Humans ; Genomic Instability ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Cell Line, Tumor ; Polo-Like Kinase 1/metabolism ; Antimitotic Agents/pharmacology ; Drug Resistance, Neoplasm
    • نبذة مختصرة :
      Mitotic duration is tightly constrained, and extended mitosis is characteristic of problematic cells prone to chromosome missegregation and genomic instability. We show here that mitotic extension leads to the formation of p53-binding protein 1 (53BP1)-ubiquitin-specific protease 28 (USP28)-p53 protein complexes that are transmitted to, and stably retained by, daughter cells. Complexes assembled through a Polo-like kinase 1-dependent mechanism during extended mitosis and elicited a p53 response in G 1 that prevented the proliferation of the progeny of cells that experienced an approximately threefold extended mitosis or successive less extended mitoses. The ability to monitor mitotic extension was lost in p53-mutant cancers and some p53-wild-type (p53-WT) cancers, consistent with classification of TP53BP1 and USP28 as tumor suppressors. Cancers retaining the ability to monitor mitotic extension exhibited sensitivity to antimitotic agents.
    • Comments:
      Comment in: Science. 2024 Mar 29;383(6690):1414-1415. (PMID: 38547295)
    • Grant Information:
      R01 GM074207 United States GM NIGMS NIH HHS
    • الرقم المعرف:
      0 (Tumor Suppressor Protein p53)
      EC 3.4.19.12 (Ubiquitin Thiolesterase)
      0 (USP28 protein, human)
      0 (TP53BP1 protein, human)
      0 (Tumor Suppressor p53-Binding Protein 1)
      0 (TP53 protein, human)
      0 (PLK1 protein, human)
      0 (Polo-Like Kinase 1)
      0 (Antimitotic Agents)
    • الموضوع:
      Date Created: 20240328 Date Completed: 20240401 Latest Revision: 20240601
    • الموضوع:
      20240601
    • الرقم المعرف:
      10.1126/science.add9528
    • الرقم المعرف:
      38547292