The Mood and Resilience in Offspring (MARIO) project: a longitudinal cohort study among offspring of parents with and without a mood disorder.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Child of Impaired Parents*/psychology ; Resilience, Psychological*; Child ; Humans ; Cohort Studies ; Longitudinal Studies ; Mood Disorders/psychology ; Parents/psychology

Background: One of the most robust risk factors for developing a mood disorder is having a parent with a mood disorder. Unfortunately, mechanisms explaining the transmission of mood disorders from one generation to the next remain largely elusive. Since timely intervention is associated with a better outcome and prognosis, early detection of intergenerational transmission of mood disorders is of paramount importance. Here, we describe the design of the Mood and Resilience in Offspring (MARIO) cohort study in which we investigate: 1. differences in clinical, biological and environmental (e.g., psychosocial factors, substance use or stressful life events) risk and resilience factors in children of parents with and without mood disorders, and 2. mechanisms of intergenerational transmission of mood disorders via clinical, biological and environmental risk and resilience factors.
Methods: MARIO is an observational, longitudinal cohort study that aims to include 450 offspring of parents with a mood disorder (uni- or bipolar mood disorders) and 100-150 offspring of parents without a mood disorder aged 10-25 years. Power analyses indicate that this sample size is sufficient to detect small to medium sized effects. Offspring are recruited via existing Dutch studies involving patients with a mood disorder and healthy controls, for which detailed clinical, environmental and biological data of the index-parent (i.e., the initially identified parent with or without a mood disorder) is available. Over a period of three years, four assessments will take place, in which extensive clinical, biological and environmental data and data on risk and resilience are collected through e.g., blood sampling, face-to-face interviews, online questionnaires, actigraphy and Experience Sampling Method assessment. For co-parents, information on demographics, mental disorder status and a DNA-sample are collected.
Discussion: The MARIO cohort study is a large longitudinal cohort study among offspring of parents with and without mood disorders. A unique aspect is the collection of granular data on clinical, biological and environmental risk and resilience factors in offspring, in addition to available parental data on many similar factors. We aim to investigate the mechanisms underlying intergenerational transmission of mood disorders, which will ultimately lead to better outcomes for offspring at high familial risk.
(© 2024. The Author(s).)

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projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw); projectnumber 6361 00004 The Netherlands Scientific Organization (ZonMw)

Keywords: Bipolar disorder; Intergenerational transmission; Major depressive disorder; Mood disorder; Resilience

Date Created: 20240327 Date Completed: 20240328 Latest Revision: 20240404

20240405

PMC10967130

10.1186/s12888-024-05555-z

38532386