Analyzing the correlation between gastroesophageal reflux disease and anxiety and depression based on ordered logistic regression.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Depression*/epidemiology ; Depression*/psychology ; Gastroesophageal Reflux*/complications ; Gastroesophageal Reflux*/epidemiology ; Gastroesophageal Reflux*/diagnosis; Male ; Female ; Humans ; Logistic Models ; Anxiety/epidemiology ; Anxiety/psychology ; Anxiety Disorders/complications

Numerous studies have indicated a connection between psychiatric symptoms, specifically anxiety and depression, and gastroesophageal reflux. However, the precise nature of the link between the severity of gastroesophageal reflux disease and the severity of anxiety and depression remains uncertain. Here, we gathered 24-h pH monitoring data and baseline patient information from a cohort of 518 individuals. Additionally, we evaluated their psychological well-being using the Hospital Anxiety and Depression Scale. The relationship between baseline characteristics and varying degrees of anxiety, depression, and gastroesophageal reflux disease (GERD) was assessed using R software version 4.1.3 and logistic regression models. The findings indicate a statistically significant variation in anxiety levels based on gender, as well as a significant disparity in depression groups when considering age and literacy levels. Kruskal-Wallis test analysis revealed a significant positive correlation between the severity of anxiety and depression and the 24-h pH monitoring results in our patient cohort. As the anxiety and depression levels increased, the rank mean for each examination result also increased. Logistic regression modeling analysis showed that a higher anxiety level was associated with a higher level of GERD. In the presence of mild anxiety, there is a statistically significant association with a higher incidence of GERD with an odds ratio (OR) of 2.64 (95% CI 1.50, 4.64). Similarly, the moderately severe anxiety group also exhibits a causal relationship with an increased GERD incidence, with an OR of 6.84 (95% CI 3.92, 12.17). Additionally, moderate to severe depression is associated with a higher incidence of GERD, with an OR of 2.32 (95% CI 1.23, 4.37). The prevalence of GERD was greater among males compared to females (OR 2.29, 95% CI 1.51-3.49). Additionally, an elevated body mass index (BMI) demonstrated a positive correlation with the susceptibility to GERD (OR 1.07, 95% CI 1.01-1.14). Increasing age may promote the occurrence of GERD in patients. These findings may help to provide a better basis for psychological or pharmacological interventions for GERD patients with psychosomatic symptoms in the future, and provide a reference basis for clinical treatment of the disease.
(© 2024. The Author(s).)

JAMA Psychiatry. 2023 Apr 1;80(4):360-370. (PMID: 36753304)
Gastroenterol Nurs. 2019 Jan/Feb;42(1):20-28. (PMID: 30688703)
Dis Mon. 2020 Jan;66(1):100848. (PMID: 30803725)
Front Public Health. 2023 Mar 28;11:1022367. (PMID: 37056646)
Am J Gastroenterol. 2023 Dec 1;118(12):2133-2143. (PMID: 37463429)
Int Rev Psychiatry. 2010;22(5):429-36. (PMID: 21047157)
Gastroenterology. 2018 Jan;154(2):267-276. (PMID: 28780072)
Int J Environ Res Public Health. 2022 Jan 10;19(2):. (PMID: 35055552)
Eur J Intern Med. 2015 Sep;26(7):534-9. (PMID: 26021838)
Dis Esophagus. 2019 May 1;32(5):. (PMID: 30561585)
Cureus. 2021 May 28;13(5):e15289. (PMID: 34194886)
Curr Opin Gastroenterol. 2017 Mar;33(2):107-111. (PMID: 28146448)
Electron Physician. 2017 Aug 01;9(8):5107-5112. (PMID: 28979749)
Gastroenterology. 2023 Oct;165(4):848-860. (PMID: 37394015)
J Gastroenterol Hepatol. 2013 Apr;28(4):626-31. (PMID: 23301662)
J Gastroenterol Hepatol. 2019 Oct;34(10):1720-1726. (PMID: 30851003)
Scand J Gastroenterol. 2017 Jan;52(1):44-49. (PMID: 27571846)
Mo Med. 2018 May-Jun;115(3):214-218. (PMID: 30228725)
Gut. 1999 Aug;45(2):172-80. (PMID: 10403727)
J Clin Gastroenterol. 2016 Jan;50(1):e1-7. (PMID: 25751371)
Psychiatry Res. 2013 Dec 30;210(3):1301-3. (PMID: 24135551)
J Psychosom Res. 2002 Feb;52(2):69-77. (PMID: 11832252)
Aliment Pharmacol Ther. 2007 Jan 1;25(1):93-101. (PMID: 17229224)
BMC Gastroenterol. 2016 Mar 15;16:36. (PMID: 26979399)
J Gastroenterol Hepatol. 2017 Jun;32(6):1170-1177. (PMID: 27862259)
BMC Gastroenterol. 2021 Mar 20;21(1):127. (PMID: 33743601)
Medicine (Baltimore). 2018 May;97(18):e0153. (PMID: 29718833)
Neurogastroenterol Motil. 2021 Sep;33(9):e14177. (PMID: 34128293)
J Clin Gastroenterol. 2016 Mar;50(3):202-7. (PMID: 26084009)
N Engl J Med. 2019 Feb 7;380(6):559-568. (PMID: 30726688)
Gut. 2018 Jul;67(7):1351-1362. (PMID: 29437910)
Turk J Gastroenterol. 2017 Dec;28(Suppl 1):S33-S37. (PMID: 29199165)
Neurosci Biobehav Rev. 2011 Aug;35(8):1757-70. (PMID: 21040743)

2023599 Chengdu Health Commission; 2021MS155 Sichuan Traditional Chinese Medicine Administration; 21PJ143 Health Commission of Sichuan Province

Keywords: 24-h esophageal pH monitoring; Anxiety; Depression; Gastroesophageal reflux disease; HADS

Date Created: 20240320 Date Completed: 20240321 Latest Revision: 20240323

20240323

PMC10951219

10.1038/s41598-024-57101-2

38503861