The Role of Polyphenols in Modulating PON1 Activity Regarding Endothelial Dysfunction and Atherosclerosis.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Cardiovascular Diseases* ; Atherosclerosis* ; Stroke* ; Dyslipidemias*; Humans ; Polyphenols ; Aryldialkylphosphatase/metabolism ; Flavonoids

The incidence and prevalence of cardiovascular diseases are still rising. The principal mechanism that drives them is atherosclerosis, an affection given by dyslipidemia and a pro-inflammatory state. Paraoxonase enzymes have a protective role due to their ability to contribute to antioxidant and anti-inflammatory pathways, especially paraoxonase 1 (PON1). PON1 binds with HDL (high-density lipoprotein), and high serum levels lead to a protective state against dyslipidemia, cardiovascular diseases, diabetes, stroke, nonalcoholic fatty liver disease, and many others. Modulating PON1 expression might be a treatment objective with significant results in limiting the prevalence of atherosclerosis. Lifestyle including diet and exercise can raise its levels, and some beneficial plants have been found to influence PON1 levels; therefore, more studies on herbal components are needed. Our purpose is to highlight the principal roles of Praoxonase 1, its implications in dyslipidemia, cardiovascular diseases, stroke, and other diseases, and to emphasize plants that can modulate PON1 expression, targeting the potential of some flavonoids that could be introduced as supplements in our diet and to validate the hypothesis that flavonoids have any effects regarding PON1 function.

Molecules. 2011 Nov 03;16(11):9207-17. (PMID: 22051932)
Exp Gerontol. 2010 Mar;45(3):243-51. (PMID: 20080168)
Clin Biochem. 2017 Dec;50(18):1298-1305. (PMID: 28779954)
World J Biol Chem. 2015 Aug 26;6(3):209-17. (PMID: 26322175)
Neurosci Biobehav Rev. 2021 Jun;125:244-263. (PMID: 33657433)
J Ethnopharmacol. 2009 Dec 10;126(3):525-32. (PMID: 19751813)
Biochem Biophys Res Commun. 2013 Jul 19;437(1):55-61. (PMID: 23791833)
Circulation. 2001 Nov 27;104(22):2638-40. (PMID: 11723010)
Antioxid Redox Signal. 2021 Jan 20;34(3):191-200. (PMID: 31969002)
Bioimpacts. 2020;10(3):159-167. (PMID: 32793438)
Plants (Basel). 2021 Dec 22;11(1):. (PMID: 35009022)
Int J Mol Sci. 2019 Aug 19;20(16):. (PMID: 31430977)
Pharmacol Rev. 2021 Jul;73(3):924-967. (PMID: 34088867)
Atherosclerosis. 2019 Jan;280:7-13. (PMID: 30448568)
Antioxidants (Basel). 2020 Sep 08;9(9):. (PMID: 32911700)
Acta Biochim Pol. 2010;57(3):321-6. (PMID: 20548972)
Oxid Med Cell Longev. 2021 Feb 05;2021:6677111. (PMID: 33628379)
J Cell Biol. 2015 Apr 13;209(1):13-22. (PMID: 25869663)
PLoS One. 2019 Jun 26;14(6):e0218934. (PMID: 31242230)
Medicine (Baltimore). 2022 Nov 18;101(46):e31553. (PMID: 36401436)
J Physiol Pharmacol. 2002 Sep;53(3):463-75. (PMID: 12369742)
Reprod Domest Anim. 2020 Jun;55(6):711-719. (PMID: 32144827)
Curr Med Chem. 2021;28(14):2842-2850. (PMID: 32674726)
Diabetes Care. 2020 Jan;43(1):178-186. (PMID: 31597668)
Ann Biol Clin (Paris). 2010 Mar-Apr;68(2):143-7. (PMID: 20348046)
Ann Clin Lab Sci. 2015 Spring;45(2):226-33. (PMID: 25887882)
Int J Environ Res Public Health. 2023 Feb 05;20(4):. (PMID: 36833509)
J Cardiovasc Pharmacol. 2000;35(4 Suppl 2):S61-63. (PMID: 10976784)
Open Cardiovasc Med J. 2010 Dec 23;4:302-12. (PMID: 21339899)
Clin Biochem. 2019 Nov;73:1-10. (PMID: 31351988)
Tohoku J Exp Med. 2007 May;212(1):43-8. (PMID: 17464102)
Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):2083-9. (PMID: 14500290)
Biochim Open. 2018 Jun 11;7:1-9. (PMID: 30003042)
BMJ. 2021 Mar 29;372:n71. (PMID: 33782057)
Free Radic Biol Med. 2011 Jan 1;50(1):102-9. (PMID: 20850524)
Nat Prod Bioprospect. 2022 Jun 16;12(1):21. (PMID: 35710954)
Pharm Biol. 2018 Dec;56(1):225-234. (PMID: 29560776)
Ann Vasc Surg. 2020 Apr;64:355-360. (PMID: 31626928)
Food Funct. 2020 Jul 1;11(7):5768-5781. (PMID: 32608443)
Dis Markers. 2022 Mar 10;2022:4264314. (PMID: 35308142)
Coron Artery Dis. 2022 Nov 1;33(7):515-522. (PMID: 36093959)
Gene. 2015 Aug 1;567(1):12-21. (PMID: 25965560)
Rev Endocr Metab Disord. 2014 Mar;15(1):45-53. (PMID: 24097125)
Per Med. 2019 Sep;16(5):379-386. (PMID: 31591927)
Clin Biochem. 2010 Apr;43(6):553-8. (PMID: 20026099)
Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62. (PMID: 27238723)
Rev Diabet Stud. 2022 Jun 30;18(2):76-92. (PMID: 35831939)
Diabetologia. 2003 Apr;46(4):593-4. (PMID: 12739030)
Atherosclerosis. 2012 May;222(1):92-8. (PMID: 22365750)
Crit Care Clin. 2020 Apr;36(2):307-321. (PMID: 32172815)
Pharmgenomics Pers Med. 2020 Oct 29;13:563-570. (PMID: 33154659)
Clin Chim Acta. 2009 Dec;410(1-2):1-12. (PMID: 19799889)
Arch Cardiol Mex. 2007 Jan-Mar;77(1):17-24. (PMID: 17500188)
Free Radic Biol Med. 2020 Jun;153:26-33. (PMID: 32244050)
Clin Biochem. 2015 Nov;48(16-17):1039-44. (PMID: 26079344)
Atherosclerosis. 2016 Feb;245:143-54. (PMID: 26724525)
South Med J. 2010 May;103(5):428-33. (PMID: 20375933)
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):386-393. (PMID: 30572120)
Sci China Life Sci. 2016 Nov;59(11):1115-1122. (PMID: 27578362)
Pan Afr Med J. 2023 May 17;45:40. (PMID: 37545608)
Cell Metab. 2011 Jan 5;13(1):11-22. (PMID: 21195345)
Clin Biochem. 2017 Sep;50(13-14):804-811. (PMID: 28433610)
BMC Cardiovasc Disord. 2022 Dec 3;22(1):521. (PMID: 36463116)
Mol Genet Metab. 2012 Jan;105(1):141-8. (PMID: 22030099)
J Nutr Health Aging. 2023;27(4):291-300. (PMID: 37170437)
Mol Med Rep. 2019 Dec;20(6):4763-4773. (PMID: 31638212)
Kardiol Pol. 2005 Jun;62(6):526-30. (PMID: 16123850)
Indian J Endocrinol Metab. 2013 May;17(3):402-12. (PMID: 23869295)
Front Biosci (Landmark Ed). 2022 Apr 20;27(4):134. (PMID: 35468693)
J Chin Med Assoc. 2022 Jan 1;85(1):77-80. (PMID: 35006126)
Molecules. 2020 Dec 17;25(24):. (PMID: 33348669)
J Nutr Biochem. 2017 Oct;48:1-8. (PMID: 28623808)
Arq Bras Cardiol. 2022 Oct;119(4):593-601. (PMID: 36074479)
J Biol Chem. 2001 Jan 19;276(3):1923-9. (PMID: 11034996)
Front Cardiovasc Med. 2023 Feb 16;10:1065967. (PMID: 36873390)
Cell Mol Biol (Noisy-le-grand). 2018 Jun 25;64(8):27-34. (PMID: 29981688)
Clin Lab. 2018 Jun 1;64(6):1049-1053. (PMID: 29945323)
Biol Pharm Bull. 2005 Nov;28(11):2158-61. (PMID: 16272711)
Pediatr Exerc Sci. 2010 Feb;22(1):93-104. (PMID: 20332543)
Biochimie. 2017 Jan;132:19-27. (PMID: 27771368)
Molecules. 2021 Apr 16;26(8):. (PMID: 33923656)
Molecules. 2023 Oct 05;28(19):. (PMID: 37836785)
Life Sci. 2019 Sep 1;232:116646. (PMID: 31302193)
Metabolism. 2003 Oct;52(10):1287-94. (PMID: 14564680)
Oxid Med Cell Longev. 2020 Feb 15;2020:3084120. (PMID: 32148648)
Pharmaceuticals (Basel). 2023 Aug 23;16(9):. (PMID: 37765009)
Atherosclerosis. 2011 Jan;214(1):20-36. (PMID: 20934178)
Br J Anaesth. 2004 Jul;93(1):105-13. (PMID: 15121728)
Curr Vasc Pharmacol. 2021;19(3):243-249. (PMID: 32316894)
Adv Exp Med Biol. 2010;660:129-42. (PMID: 20221876)
Nutrients. 2022 Jul 11;14(14):. (PMID: 35889799)
Clin Exp Med. 2023 Jun;23(2):301-311. (PMID: 35313365)
Biofactors. 2020 Mar;46(2):193-205. (PMID: 31400246)
J Clin Epidemiol. 2021 Jun;134:103-112. (PMID: 33577987)
J Hypertens. 2002 Jan;20(1):71-8. (PMID: 11791028)
Biochem Genet. 2021 Aug;59(4):919-939. (PMID: 33599870)
Atherosclerosis. 2013 Jul;229(1):71-8. (PMID: 23639858)
Vascul Pharmacol. 2018 Jan;100:1-19. (PMID: 28579545)
J Sci Food Agric. 2014 Oct;94(13):2752-7. (PMID: 25328927)
Nutrients. 2021 Apr 01;13(4):. (PMID: 33916032)
Antioxidants (Basel). 2022 Jun 27;11(7):. (PMID: 35883764)
Int J Biol Sci. 2013 Nov 09;9(10):1057-69. (PMID: 24250251)
Int J Mol Sci. 2023 Apr 12;24(8):. (PMID: 37108307)
BMC Complement Med Ther. 2020 Mar 23;20(1):98. (PMID: 32204703)
Atherosclerosis. 2013 Dec;231(2):308-14. (PMID: 24267244)
Biomolecules. 2019 Dec 03;9(12):. (PMID: 31816846)
Circ Res. 2016 Feb 19;118(4):620-36. (PMID: 26892962)
Medicine (Abingdon). 2020 Sep;48(9):561-566. (PMID: 32837228)
Semin Cancer Biol. 2019 Jun;56:72-86. (PMID: 29170064)
Atherosclerosis. 2006 Jun;186(2):396-401. (PMID: 16140307)
Clin Exp Hypertens. 2020 Aug 17;42(6):490-501. (PMID: 31965874)
Clin Exp Med. 2023 Aug;23(4):1067-1074. (PMID: 36344783)
Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):78-88. (PMID: 14579013)
J Hum Nutr Diet. 2014 Feb;27(1):1-21. (PMID: 24205990)
Arterioscler Thromb Vasc Biol. 2004 Dec;24(12):2378-83. (PMID: 15458977)
Diabetes Res Clin Pract. 2020 Mar;161:108067. (PMID: 32044348)
Int J Mol Sci. 2017 Feb 15;18(2):. (PMID: 28212288)

Keywords: atherosclerosis; cardiovascular disease; dyslipidemia; endothelial dysfunction; oxidative stress; paraoxonase 1 (PON1); polyphenols

0 (Polyphenols)
EC 3.1.8.1 (Aryldialkylphosphatase)
0 (Flavonoids)
EC 3.1.8.1 (PON1 protein, human)

Date Created: 20240313 Date Completed: 20240314 Latest Revision: 20240315

20240315

PMC10931629

10.3390/ijms25052962

38474211