The Relevance, Predictability, and Utility of Annexin A5 for Human Physiopathology.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Calcium*/metabolism ; Phosphatidylserines*/metabolism; Humans ; Annexin A5/metabolism ; Apoptosis ; Calcium, Dietary/metabolism

As an important functional protein molecule in the human body, human annexin A5 (hAnxA5) is widely found in human cells and body fluids. hAnxA5, the smallest type of annexin, performs a variety of biological functions by reversibly and specifically binding phosphatidylserine (PS) in a calcium-dependent manner and plays an important role in many human physiological and pathological processes. The free state hAnxA5 exists in the form of monomers and usually forms a polymer in a specific self-assembly manner when exerting biological activity. This review systematically discusses the current knowledge and understanding of hAnxA5 from three perspectives: physiopathological relevance, diagnostic value, and therapeutic utility. h AnxA5 affects the occurrence and development of many physiopathological processes. Moreover, hAnxA5 can be used independently or in combination as a biomarker of physiopathological phenomena for the diagnosis of certain diseases. Importantly, based on the properties of hAnxA5, many novel drug candidates have been designed and prepared for application in actual medical practice. However, there are also some gaps and shortcomings in h AnxA5 research. This in-depth study will not only expand the understanding of structural and functional relationships but also promote the application of hAnxA5 in the field of biomedicine.

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No. BNU110107977 Beijing Nomal University

Keywords: human annexin A5; phosphatidylserine (PS); physiopathology; self-assembly

0 (Annexin A5)
SY7Q814VUP (Calcium)
0 (Calcium, Dietary)
0 (Phosphatidylserines)
0 (ANXA5 protein, human)

Date Created: 20240313 Date Completed: 20240314 Latest Revision: 20240319

20250114

PMC10932194

10.3390/ijms25052865

38474114