[Epidemiological profile of pertussis in infants in Casablanca from 2012 to 2019].

Profil épidémiologique de la coqueluche du nourrisson à Casablanca de 2012 à 2019.

Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE

Original Publication: Kampala, Uganda : African Field Epidemiology Network

Whooping Cough*/epidemiology ; Whooping Cough*/prevention & control; Infant ; Infant, Newborn ; Humans ; Female ; Pregnancy ; Retrospective Studies ; Bordetella pertussis ; Mothers ; Vaccination

Competing Interests: Les auteurs ne déclarent aucun conflit d’intérêts.
Pertussis is a real public health problem due to high neonatal morbidity rates and resurgence despite high vaccination coverage. The purpose of this study is to analyze the epidemiological profile of pertussis in infants hospitalized from 2012 to 2019. We conducted a retrospective, descriptive study over a 7-year and 8-month period from January 2012 to July 2019. It involved 500 infants admitted with clinical suspicion of pertussis. The average age of infants was 72 days, ranging from 28 days to 18 months; 75% of infants were less than 3 months old. The peak incidence was registered in 2012 and 2016, with a summer predominance (32%); 460 infants (92%) were not or incompletely vaccinated, 42.2% of whom were too young to be vaccinated. A probable contaminant in the entourage was found in 43,6% of cases. Whooping cough and cyanosis were the main reason for hospitalization (77.6%). Chest radiography objectified bronchial disease (25,4%) and alveolar foci (22.7%). Blood count performed in 410 infants showed hyperlymphocytosis in 67.5% of cases. Polymerase chain reaction (PCR) on nasopharyngeal sample collected from 206 infants was positive for Bordetella pertussis in 64% of cases; 118 PCR performed in mothers were positive in 47.7% of cases. All infants received Clarithromycin. Pertussis is a major cause of morbidity in infants in Casablanca. The prevention strategy is based on vaccination of family members of infants. However, vaccination of pregnant women appears to be more effective.
(Copyright: Bouchra Slaoui et al.)

Pediatrics. 2015 Jun;135(6):e1475-82. (PMID: 25963002)
Hum Vaccin Immunother. 2015;11(1):108-17. (PMID: 25483523)
Vaccine. 2020 Jan 16;38(3):427-432. (PMID: 31685295)
BMJ. 2019 Jul 9;366:l4460. (PMID: 31289033)
BMC Infect Dis. 2017 May 16;17(1):348. (PMID: 28511667)
BMC Infect Dis. 2020 Jan 14;20(1):43. (PMID: 31937256)
Bull Acad Natl Med. 2006 Apr-May;190(4-5):1017-32; discussion 1032-3. (PMID: 17195625)
Pathog Dis. 2016 Oct;74(7):. (PMID: 27609461)
J Med Microbiol. 2019 Feb;68(2):241-247. (PMID: 30526740)
Vaccine. 2013 Jan 11;31(4):618-25. (PMID: 23200883)
Lancet Infect Dis. 2017 Sep;17(9):974-980. (PMID: 28623146)
Med Mal Infect. 2008 Sep;38(9):477-82. (PMID: 18715731)
J Infect Dev Ctries. 2016 Nov 24;10(11):1191-1199. (PMID: 27886031)
Arch Pediatr. 2009 Jul;16(7):1028-32. (PMID: 19423306)
Med Mal Infect. 2009 May;39(5):271-7. (PMID: 19362438)
Pediatrics. 2015 Oct;136(4):635-41. (PMID: 26347437)
Int J Environ Res Public Health. 2019 Nov 15;16(22):. (PMID: 31731820)
Vaccine. 2017 Oct 27;35(45):6083-6088. (PMID: 28974408)
Prim Care. 2018 Sep;45(3):423-431. (PMID: 30115332)
Infection. 2017 Apr;45(2):171-178. (PMID: 27614887)
Pediatr Infect Dis J. 2015 Aug;34(8):814-20. (PMID: 25955837)
Hum Vaccin Immunother. 2021 Mar 4;17(3):705-713. (PMID: 32755440)
Pediatr Rev. 2018 May;39(5):247-257. (PMID: 29716967)
Hum Vaccin Immunother. 2021 Apr 3;17(4):1136-1141. (PMID: 33121322)
J Infect Chemother. 2020 Jul;26(7):765-768. (PMID: 32334951)
Front Immunol. 2019 Jul 03;10:1344. (PMID: 31333640)

Keywords: Bordetella Pertussis; Pertussis; Whooping cough; epidemiology; infant

Date Created: 20240311 Date Completed: 20240312 Latest Revision: 20240312

20250114

PMC10924602

10.11604/pamj.2023.46.124.42073

38465012