Clinical features and associated factors of coexisting intracerebral hemorrhage in patients with cerebral small vessel disease: a cross-sectional study.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Original Publication: London : Nature Publishing Group, copyright 2011-

Cerebral Small Vessel Diseases*/complications ; Cerebral Small Vessel Diseases*/diagnostic imaging ; Cerebral Small Vessel Diseases*/drug therapy ; Ischemic Attack, Transient*/complications; Humans ; Cross-Sectional Studies ; Magnetic Resonance Imaging/methods ; Cerebral Hemorrhage/complications ; Cerebral Hemorrhage/diagnostic imaging

Intracerebral hemorrhage (ICH) is generally considered to be closely related to cerebral small vessel disease (CSVD), leading to a poor prognosis. However, the coexistence of ICH in general CSVD patients and related factors remain underreported. In our cross-sectional study, we screened 414 CSVD patients from a database at the Department of Neurology, First Affiliated Hospital of Zhengzhou University (September 2018 to April 2022). Imaging biomarkers of CSVD and coexisting ICH lesion were assessed. Factors associated with coexisting ICH in CSVD were determined using multivariate logistic regression analysis. ICH was observed in 59 patients (14.3%). Multivariate logistic regression showed that previous history of ischemic stroke or transient ischemic attack (OR 5.189, 95%CI 2.572-10.467, P < 0.001), high-grade perivascular space in the basal ganglia (n > 10) (OR 2.051, 95%CI 1.044-4.027, P = 0.037) and low adjusted calcium-phosphorus product (OR 0.728 per 1 [mmol/L] ² increase, 95%CI 0.531-0.998, P = 0.049) were associated with coexisting ICH in CSVD patients. The considerable proportion of coexisting ICH and revelation of associated factors in general CSVD patients alert physicians of the potential risk of the reoccurrence of ICH, and might have a significant impact on therapeutic strategies.
(© 2024. The Author(s).)

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2020-PT310-01 the Non-profit Central Research Institute and Major Science; 201300310300 Technology Projects of Henan Province in 2020

Keywords: Calcium; Cerebral small vessel disease; Intracerebral hemorrhage; Phosphorus

Date Created: 20240307 Date Completed: 20240311 Latest Revision: 20240311

20240311

PMC10920749

10.1038/s41598-024-55968-9

38454101