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The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome.
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- معلومة اضافية
- المصدر:
Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium: Internet ISSN: 1742-2094 (Electronic) Linking ISSN: 17422094 NLM ISO Abbreviation: J Neuroinflammation Subsets: MEDLINE
- بيانات النشر:
Original Publication: [London] : BioMed Central, c2004-
- الموضوع:
- نبذة مختصرة :
Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss, characterised by the dysfunction and death of the photoreceptors and retinal pigment epithelium (RPE). Innate immune cell activation and accompanying para-inflammation have been suggested to contribute to the pathogenesis of AMD, although the exact mechanism(s) and signalling pathways remain elusive. Pattern recognition receptors (PRRs) are essential activators of the innate immune system and drivers of para-inflammation. Of these PRRs, the two most prominent are (1) Toll-like receptors (TLR) and (2) NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3)-inflammasome have been found to modulate the progression of AMD. Mutations in TLR2 have been found to be associated with an increased risk of developing AMD. In animal models of AMD, inhibition of TLR and NLRP3 has been shown to reduce RPE cell death, inflammation and angiogenesis signalling, offering potential novel treatments for advanced AMD. Here, we examine the evidence for PRRs, TLRs2/3/4, and NLRP3-inflammasome pathways in macular degeneration pathogenesis.
(© 2024. The Author(s).)
- References:
Nat Med. 2014 Dec;20(12):1376-7. (PMID: 25473915)
N Engl J Med. 2006 Oct 5;355(14):1419-31. (PMID: 17021318)
Sci Rep. 2018 Apr 30;8(1):6720. (PMID: 29712950)
Hum Mol Genet. 2005 Jun 1;14(11):1449-55. (PMID: 15829498)
Front Cell Neurosci. 2019 Feb 27;13:59. (PMID: 30873007)
Am J Pathol. 2017 Oct;187(10):2208-2221. (PMID: 28739342)
Graefes Arch Clin Exp Ophthalmol. 2015 Nov;253(11):1941-5. (PMID: 26148801)
Invest Ophthalmol Vis Sci. 2012 Nov 07;53(12):7528-38. (PMID: 23074202)
Toxicol Appl Pharmacol. 2017 Mar 1;318:58-68. (PMID: 28126413)
Invest Ophthalmol Vis Sci. 2020 Oct 1;61(12):25. (PMID: 33107904)
Autophagy. 2023 Jan;19(1):92-111. (PMID: 35473441)
J Biol Chem. 2011 Apr 29;286(17):15543-55. (PMID: 21383019)
Curr Eye Res. 2023 May;48(5):474-484. (PMID: 36591949)
Ophthalmic Res. 2010;44(4):237-41. (PMID: 20699627)
Immunol Lett. 2012 Sep;147(1-2):29-33. (PMID: 22698681)
Cochrane Database Syst Rev. 2014 Aug 29;(8):CD005139. (PMID: 25170575)
Science. 2014 Nov 21;346(6212):1000-3. (PMID: 25414314)
Invest Ophthalmol Vis Sci. 2013 Nov 11;54(12):7395-401. (PMID: 24114535)
Signal Transduct Target Ther. 2021 Apr 14;6(1):149. (PMID: 33850097)
Clin Exp Immunol. 2007 Jan;147(1):71-80. (PMID: 17177965)
Biochem Pharmacol. 2021 May;187:114385. (PMID: 33359010)
Int J Mol Sci. 2021 Jul 22;22(15):. (PMID: 34360582)
Ophthalmology. 2016 Jun;123(6):1320-31. (PMID: 27039021)
J Biochem Mol Toxicol. 2017 Jun;31(6):. (PMID: 28004443)
Nat Rev Immunol. 2020 Feb;20(2):95-112. (PMID: 31558839)
Exp Eye Res. 2019 Nov;188:107771. (PMID: 31445901)
Nat Genet. 2016 Feb;48(2):134-43. (PMID: 26691988)
Nature. 2008 Apr 3;452(7187):591-7. (PMID: 18368052)
Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1652-9. (PMID: 18385087)
Nature. 2006 Mar 9;440(7081):237-41. (PMID: 16407889)
PLoS One. 2012;7(7):e40510. (PMID: 22808176)
Diabetol Metab Syndr. 2015 Oct 13;7:89. (PMID: 26468333)
N Engl J Med. 2008 Oct 2;359(14):1456-63. (PMID: 18753640)
Ophthalmic Res. 2011;45(4):191-6. (PMID: 21079408)
Curr Eye Res. 2019 Jan;44(1):67-75. (PMID: 30198786)
Invest Ophthalmol Vis Sci. 2004 Jun;45(6):1871-8. (PMID: 15161852)
Nat Med. 2014 Dec;20(12):1372-5. (PMID: 25473914)
Mol Ther. 2012 Jan;20(1):101-8. (PMID: 21988875)
Cell Rep. 2020 Feb 18;30(7):2209-2224.e5. (PMID: 32075760)
Prog Retin Eye Res. 2009 Sep;28(5):348-68. (PMID: 19560552)
J Gen Physiol. 2004 Aug;124(2):139-49. (PMID: 15277575)
Nat Rev Immunol. 2021 Sep;21(9):548-569. (PMID: 33833439)
Exp Eye Res. 2021 May;206:108557. (PMID: 33789141)
Nat Rev Immunol. 2007 May;7(5):353-64. (PMID: 17457343)
Elife. 2020 Dec 11;9:. (PMID: 33305736)
Neurol Sci. 2013 Aug;34(8):1339-46. (PMID: 23207548)
Nat Rev Immunol. 2014 Aug;14(8):546-58. (PMID: 25060580)
Am J Ophthalmol. 1992 Oct 15;114(4):464-72. (PMID: 1415458)
Invest Ophthalmol Vis Sci. 2016 Nov 01;57(14):5843-5855. (PMID: 27802514)
Front Immunol. 2014 Sep 25;5:461. (PMID: 25309543)
PLoS One. 2015 Mar 13;10(3):e0119541. (PMID: 25767877)
Antioxid Redox Signal. 2015 May 1;22(13):1111-29. (PMID: 25330206)
Nature. 1980 Apr 17;284(5757):604-7. (PMID: 7366731)
J Immunol. 2003 Apr 1;170(7):3451-4. (PMID: 12646604)
J Clin Invest. 2007 Oct;117(10):2920-8. (PMID: 17909628)
Cell. 2012 May 11;149(4):847-59. (PMID: 22541070)
N Engl J Med. 2007 Aug 9;357(6):553-61. (PMID: 17634448)
Appl Biochem Biotechnol. 2016 Jan;178(2):368-81. (PMID: 26467741)
PLoS One. 2015 May 15;10(5):e0125150. (PMID: 25978536)
Exp Eye Res. 2003 Mar;76(3):321-31. (PMID: 12573661)
J Immunol. 2002 May 15;168(10):5233-9. (PMID: 11994480)
Front Immunol. 2012 Nov 27;3:338. (PMID: 23230433)
J Leukoc Biol. 2003 Jul;74(1):25-32. (PMID: 12832439)
Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3820-4. (PMID: 20130283)
J Exp Med. 2002 Jan 7;195(1):99-111. (PMID: 11781369)
Exp Eye Res. 2022 Mar;216:108943. (PMID: 35074346)
Nat Immunol. 2008 Aug;9(8):857-65. (PMID: 18604209)
J Neurosci. 2004 Jan 7;24(1):1-7. (PMID: 14715932)
Trends Biochem Sci. 2016 Dec;41(12):1012-1021. (PMID: 27669650)
J Histochem Cytochem. 2014 Oct;62(10):698-738. (PMID: 25062998)
Clin Ophthalmol. 2017 Jul 26;11:1347-1358. (PMID: 28794612)
Sci Rep. 2018 Jan 11;8(1):461. (PMID: 29323137)
PLoS One. 2013 Jun 28;8(6):e67263. (PMID: 23840644)
Cell Biosci. 2022 Jul 25;12(1):116. (PMID: 35879806)
Prog Retin Eye Res. 2008 Nov;27(6):596-607. (PMID: 18848639)
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2328-33. (PMID: 16452172)
JCI Insight. 2017 Feb 23;2(4):e92340. (PMID: 28239662)
Oncoimmunology. 2012 May 1;1(3):271-278. (PMID: 22737602)
PLoS One. 2015 Jun 19;10(6):e0130624. (PMID: 26091541)
Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3034-3045. (PMID: 31311035)
Genet Mol Res. 2014 Jan 17;13(1):302-9. (PMID: 24535857)
Sci Rep. 2016 Feb 05;6:20639. (PMID: 26847702)
Graefes Arch Clin Exp Ophthalmol. 2021 Feb;259(2):413-424. (PMID: 32949301)
Immunity. 2018 Jan 16;48(1):35-44.e6. (PMID: 29195811)
Exp Eye Res. 2000 Apr;70(4):441-9. (PMID: 10865992)
Nat Rev Immunol. 2016 Jan;16(1):35-50. (PMID: 26711677)
Mol Vis. 2009;15:619-28. (PMID: 19347047)
PLoS One. 2012;7(1):e29830. (PMID: 22253793)
Cell Physiol Biochem. 2018;49(1):359-367. (PMID: 30138927)
Front Immunol. 2021 Nov 08;12:769242. (PMID: 34819935)
JAMA Ophthalmol. 2022 Mar 01;140(3):243-249. (PMID: 35113137)
Science. 2010 Nov 5;330(6005):841-5. (PMID: 20966214)
Exp Eye Res. 2018 Aug;173:73-84. (PMID: 29698675)
J Neuroinflammation. 2019 Jun 6;16(1):118. (PMID: 31170999)
J Physiol. 2018 Apr 15;596(8):1397-1417. (PMID: 29380370)
Exp Neurol. 2015 May;267:1-12. (PMID: 25725353)
J Mol Neurosci. 2020 Jun;70(6):968-980. (PMID: 32072483)
J Neurochem. 2009 Jan;108(1):115-25. (PMID: 19014371)
Mediators Inflamm. 2014;2014:930671. (PMID: 25214719)
Cell Death Differ. 2018 Jan;25(1):180-189. (PMID: 28885615)
FASEB J. 2011 Oct;25(10):3489-95. (PMID: 21712495)
Cell Death Discov. 2016 Jul 04;2:16054. (PMID: 27551542)
Mol Vis. 2002 Apr 21;8:119-26. (PMID: 11979237)
Hum Mol Genet. 2016 Apr 15;25(8):1501-16. (PMID: 27008885)
Prog Retin Eye Res. 2017 Nov;61:98-128. (PMID: 28602950)
Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):801-811. (PMID: 28152141)
Ophthalmology. 2013 Nov;120(11):2292-9. (PMID: 23642856)
Lancet. 2022 Feb 19;399(10326):729-740. (PMID: 35085502)
J Neuroimmunol. 2018 Sep 15;322:26-35. (PMID: 29954626)
Arch Ophthalmol. 1998 Dec;116(12):1629-32. (PMID: 9869793)
Br J Ophthalmol. 2010 Jul;94(7):918-25. (PMID: 19965817)
Invest Ophthalmol Vis Sci. 2013 Jan 07;54(1):110-20. (PMID: 23221073)
Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24100-24107. (PMID: 31712411)
Exp Eye Res. 2003 Apr;76(4):463-71. (PMID: 12634111)
Curr Rheumatol Rep. 2013 May;15(5):323. (PMID: 23516014)
PLoS Med. 2006 Jan;3(1):e5. (PMID: 16300415)
Front Cell Neurosci. 2017 Aug 08;11:227. (PMID: 28848393)
Glia. 2014 Apr;62(4):592-607. (PMID: 24470356)
Curr Eye Res. 2016 Jun;41(6):856-61. (PMID: 26398587)
Int J Mol Sci. 2021 Jun 25;22(13):. (PMID: 34202223)
Invest Ophthalmol Vis Sci. 2015 Feb 12;56(3):1658-64. (PMID: 25678688)
J Neuroinflammation. 2022 Oct 8;19(1):251. (PMID: 36209107)
Exp Eye Res. 2004 Feb;78(2):243-56. (PMID: 14729357)
Arterioscler Thromb Vasc Biol. 2011 May;31(5):1024-32. (PMID: 21372296)
J Neuroinflammation. 2017 Jul 17;14(1):135. (PMID: 28716092)
Cell Rep. 2015 Jun 23;11(11):1686-93. (PMID: 26074074)
Ophthalmic Genet. 2021 Dec;42(6):641-649. (PMID: 34287094)
Invest Ophthalmol Vis Sci. 2006 Apr;47(4):1255-63. (PMID: 16565355)
J Mol Med (Berl). 2009 Feb;87(2):117-23. (PMID: 19009282)
Immunity. 2017 Jul 18;47(1):15-31. (PMID: 28723547)
Genome Biol. 2011 Dec 28;12(12):236. (PMID: 22204421)
Lancet. 2023 Apr 29;401(10386):1459-1472. (PMID: 36996856)
Nat Rev Immunol. 2019 Aug;19(8):477-489. (PMID: 31036962)
Br J Ophthalmol. 2005 Jul;89(7):904-10. (PMID: 15965176)
Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. (PMID: 18172114)
Invest Ophthalmol Vis Sci. 2013 Mar 01;54(3):2225-37. (PMID: 23462752)
Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4694-702. (PMID: 20393111)
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5697-707. (PMID: 20538986)
Glia. 2014 Sep;62(9):1486-501. (PMID: 24839011)
Am J Physiol Cell Physiol. 2006 Mar;290(3):C917-24. (PMID: 16267105)
Lab Invest. 2016 Nov;96(11):1178-1188. (PMID: 27668890)
J Neuroinflammation. 2018 Jan 12;15(1):15. (PMID: 29329580)
Arterioscler Thromb Vasc Biol. 2013 Feb;33(2):330-8. (PMID: 23241411)
Ophthalmology. 2018 Jul;125(7):1037-1046. (PMID: 29454660)
Cells. 2021 Jun 02;10(6):. (PMID: 34199501)
Lancet Glob Health. 2014 Feb;2(2):e106-16. (PMID: 25104651)
J Neuroinflammation. 2023 Oct 20;20(1):239. (PMID: 37864169)
Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1881-91. (PMID: 23766263)
J Inflamm (Lond). 2014 Jul 16;11:20. (PMID: 25089120)
Sci Rep. 2021 Aug 2;11(1):15612. (PMID: 34341398)
Surv Ophthalmol. 2000 Sep-Oct;45(2):115-34. (PMID: 11033038)
ScientificWorldJournal. 2011 Apr 19;11:981-91. (PMID: 21516292)
PLoS One. 2012;7(5):e36560. (PMID: 22615780)
Science. 2023 Jan 6;379(6627):45-62. (PMID: 36603072)
Int Immunol. 2005 Jan;17(1):1-14. (PMID: 15585605)
Infect Immun. 2012 Jun;80(6):2076-88. (PMID: 22431652)
Br J Ophthalmol. 2021 Feb;105(2):151-157. (PMID: 32269060)
Am J Ophthalmol. 2002 Sep;134(3):411-31. (PMID: 12208254)
Exp Eye Res. 2018 Apr;169:99-110. (PMID: 29425879)
Cold Spring Harb Perspect Med. 2014 May 05;4(7):a017194. (PMID: 24799364)
Front Immunol. 2022 Jan 05;12:736261. (PMID: 35069523)
Trans Am Ophthalmol Soc. 2005;103:126-35; discussion 135-7. (PMID: 17057796)
J Proteome Res. 2006 Apr;5(4):862-78. (PMID: 16602694)
Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5614-8. (PMID: 19628747)
Nature. 2011 Mar 17;471(7338):325-30. (PMID: 21297615)
J Ocul Pharmacol Ther. 2018 Sep;34(7):489-499. (PMID: 30188257)
FASEB J. 2020 May;34(5):6437-6448. (PMID: 32190930)
N Engl J Med. 2008 Jun 12;358(24):2606-17. (PMID: 18550876)
J Neurochem. 2013 Jul;126(2):243-60. (PMID: 23574143)
Front Cell Neurosci. 2021 Apr 23;15:659843. (PMID: 33967697)
Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3729-35. (PMID: 16936080)
Curr Drug Targets. 2017;18(9):1003-1018. (PMID: 27660056)
EMBO Mol Med. 2013 Nov;5(11):1775-93. (PMID: 24142887)
Invest Ophthalmol Vis Sci. 2014 Aug 05;55(9):5466-75. (PMID: 25097240)
Hum Mol Genet. 2023 May 5;32(10):1698-1710. (PMID: 36645183)
Int J Mol Sci. 2019 Jul 06;20(13):. (PMID: 31284572)
J Immunol. 2010 Nov 1;185(9):5486-94. (PMID: 20876352)
Trends Immunol. 2018 May;39(5):393-406. (PMID: 29452983)
Mol Vis. 1999 Nov 03;5:32. (PMID: 10562656)
Exp Eye Res. 2015 Sep;138:114-23. (PMID: 26091789)
J Tissue Eng Regen Med. 2017 Jun;11(6):1779-1791. (PMID: 26205614)
Exp Eye Res. 2021 Sep;210:108716. (PMID: 34352266)
Graefes Arch Clin Exp Ophthalmol. 2015 May;253(5):699-704. (PMID: 25056526)
Nat Med. 2009 Jul;15(7):774-80. (PMID: 19561617)
Lancet Glob Health. 2017 Dec;5(12):e1221-e1234. (PMID: 29032195)
Neurobiol Aging. 2017 Mar;51:71-82. (PMID: 28039766)
Semin Immunopathol. 2018 Jan;40(1):37-48. (PMID: 28842749)
Mol Aspects Med. 2020 Dec;76:100924. (PMID: 33187725)
Nat Med. 2012 May;18(5):791-8. (PMID: 22484808)
Nat Med. 2018 Jan;24(1):50-61. (PMID: 29176737)
Mol Ther Nucleic Acids. 2017 Sep 15;8:132-143. (PMID: 28918016)
Front Mol Neurosci. 2019 Mar 13;12:36. (PMID: 30930743)
J Neuroimmunol. 2004 Aug;153(1-2):7-15. (PMID: 15265658)
Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):202-208. (PMID: 30644965)
J Biol Chem. 2002 Apr 26;277(17):15028-34. (PMID: 11836257)
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5470-9. (PMID: 20505194)
Cell Death Dis. 2017 Jan 5;8(1):e2537. (PMID: 28055007)
Lab Invest. 2009 Mar;89(3):278-89. (PMID: 19139725)
Ophthalmologica. 2012;227(1):1-19. (PMID: 21921569)
Mol Vis. 2013 Aug 06;19:1826-33. (PMID: 23946637)
Mol Cell Biochem. 2014 Aug;393(1-2):1-8. (PMID: 24682730)
PLoS One. 2019 Aug 19;14(8):e0220887. (PMID: 31425537)
J Mol Med (Berl). 2015 Aug;93(8):905-16. (PMID: 25783493)
- Contributed Indexing:
Keywords: Age related macular degeneration; Innate immunity; Microglia; NLRP3; NOD-1 like; P2 × 7; Pattern recognition receptor; Retinal degeneration; Toll-like receptors
- الرقم المعرف:
0 (Inflammasomes)
0 (NLR Family, Pyrin Domain-Containing 3 Protein)
0 (Toll-Like Receptors)
- الموضوع:
Date Created: 20240305 Date Completed: 20240307 Latest Revision: 20240307
- الموضوع:
20240307
- الرقم المعرف:
PMC10913318
- الرقم المعرف:
10.1186/s12974-024-03055-1
- الرقم المعرف:
38443987
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