Changes in suicidal ideation during treatment among patients with major depressive disorder: A 6-month naturalistic follow-up study.

Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101719700 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-173X (Electronic) Linking ISSN: 2574173X NLM ISO Abbreviation: Neuropsychopharmacol Rep Subsets: MEDLINE

Original Publication: [Hoboken, NJ] : John Wiley & Sons, Inc., [2018]-

Depressive Disorder, Major*/psychology ; Depressive Disorder, Major*/diagnosis ; Suicidal Ideation*; Humans ; Male ; Female ; Adult ; Cross-Sectional Studies ; Middle Aged ; Follow-Up Studies ; Longitudinal Studies ; Antidepressive Agents/therapeutic use

Aim: There is limited evidence regarding predictors of changes in suicidal ideation (SI) in patients with major depressive disorder (MDD). The objective of this study was to describe changes in SI over a 6-month period and identify their predictors from naturalistic observations of MDD patients.
Methods: In the cross-sectional analysis, we examined 257 patients with MDD at the first-visit assessment. Among the patients, 119 who completed the 6-month assessment (completers) were included in the longitudinal analysis. For the evaluation of depressive symptoms, including SI, the Quick Inventory of Depressive Symptomatology-Japanese version was administered at both the first-visit and follow-up assessments. At baseline, we also administered the Japanese version of the Ten Item Personality Inventory to assess personality traits and the PRIME Screen-Revised to assess psychotic symptoms.
Results: In the cross-sectional analysis of first-visit patients, 36.2% (93/257) exhibited SI. Among completers, 14.3% (17/119) had prolonged SI. Among the completers with SI at the first-visit assessment, 38.6% (17/44) had SI at the follow-up assessment (prolonged SI). In linear regression models including all completers, prolonged SI was positively associated with endorsement of suspiciousness/persecutory ideas and negatively associated with higher age.
Conclusion: More than one-third of completers who had SI at the first-visit assessment experienced prolonged SI (SI at follow-up). Our findings can help clinicians predict the course of MDD by identifying associated demographic and clinical characteristics.
(© 2024 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.)

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Keywords: major depressive disorder; naturalistic study; predictive factor; suicide ideation

0 (Antidepressive Agents)

Date Created: 20240305 Date Completed: 20240603 Latest Revision: 20240605

20240605

PMC11144608

10.1002/npr2.12428

38443150