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Cross-sectional, comparative study of health-related quality of life across the adult lifespan in multiple sclerosis.

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  • المؤلفون: Huynh TLT;Huynh TLT; Feasel CD; Feasel CD; Jeng B; Jeng B; Motl RW; Motl RW
  • المصدر:
    The International journal of neuroscience [Int J Neurosci] 2025 Jun; Vol. 135 (6), pp. 718-725. Date of Electronic Publication: 2024 Mar 13.
  • نوع النشر :
    Journal Article; Comparative Study
  • اللغة:
    English
  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1563-5279 (Electronic) Linking ISSN: 00207454 NLM ISO Abbreviation: Int J Neurosci Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: New York, Gordon and Breach.
    • الموضوع:
      Quality of Life*/psychology ; Multiple Sclerosis*/psychology ; Multiple Sclerosis*/physiopathology ; Aging*/psychology; Humans ; Male ; Female ; Middle Aged ; Adult ; Cross-Sectional Studies ; Aged ; Young Adult ; Surveys and Questionnaires ; Age Factors
    • نبذة مختصرة :
      Purpose: This study examines the independent and interactive effects of age and multiple sclerosis (MS) on health-related quality of life (HRQOL).
      Materials and Methods: The sample included persons with MS ( n =  207) and healthy controls (HCs; n  = 99) divided into three age groups (young, middle-aged, and older adults) who completed a battery of questionnaires, including the 36-item Short-Form Health Survey (SF-36) as a measure of HRQOL. The SF-36 yielded scores for the Physical Component Summary (PCS) (i.e. physical HRQOL) and Mental Component Summary (MCS) (i.e. mental HRQOL). The data were analyzed using two-way MANOVA.
      Results: There was no interaction between age and disease status on HRQOL, but there were significant main effects of age and disease status on HRQOL. HRQOL was significantly lower in participants with MS than HCs, regardless of age. Physical HRQOL was lower, whereas mental HRQOL was higher across age groups.
      Conclusion: The findings suggest that future research should develop behavioral and rehabilitation approaches that are applicable for improving HRQOL across the lifespan in persons with MS, particularly for physical HRQOL in older adults with MS.
    • Contributed Indexing:
      Keywords: Multiple sclerosis; age; disease status; physical quality of life, mental quality of life
    • الموضوع:
      Date Created: 20240305 Date Completed: 20250601 Latest Revision: 20250601
    • الموضوع:
      20250602
    • الرقم المعرف:
      10.1080/00207454.2024.2327404
    • الرقم المعرف:
      38441501