A Prospective Clinical Study of Bacteriological Profile and their Antibiotic Susceptibilty Profile in Patients with Chronic Rhinosinusitis: The Recent Scenario in Northern India.

Publisher: Springer Country of Publication: India NLM ID: 9422551 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2231-3796 (Print) Linking ISSN: 22313796 NLM ISO Abbreviation: Indian J Otolaryngol Head Neck Surg Subsets: PubMed not MEDLINE

Publication: <2007>- : New Delhi : Springer
Original Publication: Calcutta : B.K. Roy Chaudhuri, [1993-

Objectives: 1. To determine the prevailing scenario of the bacteriological profile of patients with CRS, 2. To identify their antibiotic susceptibility profile.
Material and Methods: The study was conducted on 100 patients in the Department of ENT and Microbiology from December 2020-2022. Patients above the age of 12 years were evaluated. Those who received antibiotics in the last 12 months. and age < 12 years were excluded. Patients were subjected to a detailed history, clinical and radiological examination. After the informed consent of patients and ethical cleareance, samples were taken from the middle meatus area and studied for antibiotics sensitivity: levofloxacin, vancomycin, amikacin, amoxicillin-clavulanic acid and azithromycin.
Results: The study was male predominance (71%), with the maximum of patients in the age group 21-30 years (38%). The most common clinical features were nasal obstruction ( 96%) and mucopurulent discharge (100%). The most common isolate was Staphylococcus aureus (45.16%). In Gram-positive, the maximum resistance was shown to azithromycin and amoxicillin-clavulanic acid and the maximum sensitivity to vancomycin, levofloxacin and amikacin.
Conclusions: Antibiotic resistance seems to be emerging for azithromycin and amoxicillin-clavulanic acid at a higher rate. MRSA ( 19.35%) maintains a significant presence with associated increased levels of antibiotic resistance.
Competing Interests: Conflict of InterestNone.
(© Association of Otolaryngologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)

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Keywords: Antibiotics; Bacteriology; Microbiology Culture; Middle meatus; Rhinosinusitis

Date Created: 20240305 Latest Revision: 20240306

20240306

PMC10908880

10.1007/s12070-023-04242-x

38440469