A systematic review of the mechanistic actions of microRNAs within integrated traditional Chinese medicine and western medical treatment for endometriosis.

Publisher: Shandong University China-Japan Cooperation Center for Drug Discovery & Screen Country of Publication: Japan NLM ID: 101493809 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-784X (Electronic) Linking ISSN: 18817831 NLM ISO Abbreviation: Drug Discov Ther

Original Publication: [Tokyo] : Shandong University China-Japan Cooperation Center for Drug Discovery & Screen : International Advancement Center for Medicine & Health Research

Endometriosis*/drug therapy ; Endometriosis*/genetics ; MicroRNAs*/genetics ; Medicine, Chinese Traditional*/methods; Humans ; Female ; Gene Expression Regulation/drug effects ; Drugs, Chinese Herbal/therapeutic use ; Drugs, Chinese Herbal/pharmacology

Endometriosis (EM), also known as Zhengjia in traditional Chinese medicine, is a common disease that significantly impacts women's health. An integrated treatment approach combining traditional Chinese medicine (TCM) and western medicine has demonstrated significant clinical efficacy in the management of this condition. Specifically, it has been effective in addressing blood circulation and other diseases. MicroRNAs (miRNAs), which are molecules important in gene regulation, have been implicated in various physiologic and pathologic processes. In this review, we systematically summarized the potential mechanisms underlying the integrated EM treatment, with a focus on the role of microRNAs (miRNAs). Current research suggests that integrated TCM and western medicine treatment may exert their therapeutic effects on EM by influencing the expression of miRNAs. Through miRNA modulation, such a treatment approach may inhibit the growth of ectopic lesions and alleviate clinical symptoms. This review will shed light on the specific miRNAs that have been implicated in the integrated treatment of EM, as well as their potential mechanisms of action. By consolidating the existing evidence, we aim to provide clinicians and researchers with a clearer understanding of the therapeutic benefits of the integrated approach and potentially identify new avenues for improving clinical treatment outcomes. Ultimately, this review will contribute to the growing body of knowledge in this field, providing a basis for further research and the development of more targeted and efficient treatment strategies for EM.

Keywords: endometriosis; herb; microRNA; traditional Chinese medicine

0 (MicroRNAs)
0 (Drugs, Chinese Herbal)

Date Created: 20240228 Date Completed: 20240807 Latest Revision: 20240807

20240808

10.5582/ddt.2024.01004

38417896