Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Autophagy and oxidative stress modulation mediate Bortezomib resistance in prostate cancer.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- معلومة اضافية
- المصدر:
Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- بيانات النشر:
Original Publication: San Francisco, CA : Public Library of Science
- الموضوع:
- نبذة مختصرة :
Proteasome inhibitors such as Bortezomib represent an established type of targeted treatment for several types of hematological malignancies, including multiple myeloma, Waldenstrom's macroglobulinemia, and mantle cell lymphoma, based on the cancer cell's susceptibility to impairment of the proteasome-ubiquitin system. However, a major problem limiting their efficacy is the emergence of resistance. Their application to solid tumors is currently being studied, while simultaneously, a wide spectrum of hematological cancers, such as Myelodysplastic Syndromes show minimal or no response to Bortezomib treatment. In this study, we utilize the prostate cancer cell line DU-145 to establish a model of Bortezomib resistance, studying the underlying mechanisms. Evaluating the resulting resistant cell line, we observed restoration of proteasome chymotrypsin-like activity, regardless of drug presence, an induction of pro-survival pathways, and the substitution of the Ubiquitin-Proteasome System role in proteostasis by induction of autophagy. Finally, an estimation of the oxidative condition of the cells indicated that the resistant clones reduce the generation of reactive oxygen species induced by Bortezomib to levels even lower than those induced in non-resistant cells. Our findings highlight the role of autophagy and oxidative stress regulation in Bortezomib resistance and elucidate key proteins of signaling pathways as potential pharmaceutical targets, which could increase the efficiency of proteasome-targeting therapies, thus expanding the group of molecular targets for neoplastic disorders.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Zafeiropoulou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- References:
Cells. 2020 Sep 29;9(10):. (PMID: 33003453)
Signal Transduct Target Ther. 2023 May 10;8(1):196. (PMID: 37164974)
Exp Ther Med. 2015 Sep;10(3):1219-1223. (PMID: 26622468)
Cell Death Dis. 2013 Feb 28;4:e512. (PMID: 23449448)
Acta Pharmacol Sin. 2011 May;32(5):619-25. (PMID: 21499287)
J Nucl Med. 2012 Nov;53(11):1764-71. (PMID: 23055533)
Mol Cancer Ther. 2008 Sep;7(9):2866-75. (PMID: 18790767)
Pharmacol Res. 2016 Mar;105:210-5. (PMID: 26827824)
J Exp Clin Cancer Res. 2010 Jan 22;29:8. (PMID: 20096120)
Cancers (Basel). 2019 Aug 14;11(8):. (PMID: 31416295)
J Clin Med. 2020 Feb 18;9(2):. (PMID: 32085480)
Mol Oncol. 2020 Apr;14(4):763-778. (PMID: 31955515)
Cells. 2021 Sep 02;10(9):. (PMID: 34571936)
Clin Cancer Res. 2007 Feb 15;13(4):1208-15. (PMID: 17317831)
PLoS One. 2020 Jul 28;15(7):e0232565. (PMID: 32722676)
Prog Biophys Mol Biol. 2021 Oct;165:3-7. (PMID: 33991583)
Cell Discov. 2020 Feb 11;6:6. (PMID: 32047650)
Am J Pathol. 2011 May;178(5):2109-20. (PMID: 21514426)
Autophagy. 2008 Feb;4(2):141-50. (PMID: 17986870)
Cancer Res. 2001 Apr 1;61(7):3071-6. (PMID: 11306489)
Oncotarget. 2016 Nov 22;7(47):77622-77634. (PMID: 27769058)
Sci Rep. 2014 Jul 31;4:5896. (PMID: 25077633)
J Biol Chem. 1999 Jun 18;274(25):17580-6. (PMID: 10364193)
Mol Cell. 2001 Aug;8(2):317-25. (PMID: 11545734)
Cancer Res. 2004 Aug 1;64(15):5036-43. (PMID: 15289299)
Crit Care Med. 2000 Apr;28(4 Suppl):N67-77. (PMID: 10807318)
Leukemia. 2010 Aug;24(8):1506-12. (PMID: 20555361)
Chem Biol. 2001 Aug;8(8):739-58. (PMID: 11514224)
J Biol Chem. 2014 Sep 5;289(36):24944-55. (PMID: 25049227)
J Hematol Oncol. 2020 Nov 25;13(1):159. (PMID: 33239065)
Clin Cancer Res. 2005 Aug 1;11(15):5526-33. (PMID: 16061869)
Cell Death Differ. 2011 Apr;18(4):571-80. (PMID: 21311563)
Ann Oncol. 2006 May;17(5):813-7. (PMID: 16403809)
J Invest Dermatol. 2016 Jul;136(7):1479-1489. (PMID: 26970356)
Cancer Invest. 2004;22(2):304-11. (PMID: 15199612)
J Biol Chem. 2014 May 2;289(18):12612-22. (PMID: 24627483)
J Cell Sci. 2019 Sep 26;132(18):. (PMID: 31427430)
Curr Opin Genet Dev. 2010 Feb;20(1):87-90. (PMID: 20006486)
PLoS One. 2020 Dec 17;15(12):e0244255. (PMID: 33332446)
Blood. 2006 Jun 15;107(12):4907-16. (PMID: 16507771)
Ther Adv Hematol. 2016 Aug;7(4):196-208. (PMID: 27493710)
Clin Cancer Res. 2008 Nov 15;14(22):7511-8. (PMID: 19010869)
Am J Pathol. 2007 Aug;171(2):513-24. (PMID: 17620365)
Curr Opin Cell Biol. 1995 Apr;7(2):215-23. (PMID: 7612274)
Clin Lung Cancer. 2004 Nov;6(3):141-2. (PMID: 15555213)
Oncotarget. 2015 Apr 20;6(11):8567-78. (PMID: 25895124)
Clin Cancer Res. 2011 Aug 1;17(15):5101-12. (PMID: 21712452)
Cancer Res. 1999 Jun 1;59(11):2615-22. (PMID: 10363983)
Anticancer Drugs. 2007 Jul;18(6):677-86. (PMID: 17762396)
Biochem Res Int. 2012;2012:832059. (PMID: 22811914)
Lung Cancer. 2010 Apr;68(1):89-93. (PMID: 19524318)
J Biol Chem. 2013 May 24;288(21):14959-72. (PMID: 23576438)
Drugs. 2009;69(7):859-88. (PMID: 19441872)
Anticancer Drugs. 2006 Apr;17(4):455-62. (PMID: 16550004)
Nutr Cancer. 2021;73(7):1217-1227. (PMID: 32698628)
J Cell Biochem. 2001 Apr 2-27;82(1):110-22. (PMID: 11400168)
PLoS One. 2012;7(2):e30975. (PMID: 22383985)
Cell Stress Chaperones. 2020 Mar;25(2):357-367. (PMID: 32026316)
Am J Cancer Res. 2022 Jul 15;12(7):3280-3293. (PMID: 35968359)
Cancer Cell Int. 2005 Jun 01;5(1):18. (PMID: 15929791)
Drug Resist Updat. 2018 Nov;41:1-25. (PMID: 30471641)
Methods Enzymol. 2014;542:25-57. (PMID: 24862259)
Autophagy. 2015;11(2):200-13. (PMID: 25714619)
Clinics (Sao Paulo). 2022 Sep 8;77:100076. (PMID: 36088885)
Int J Mol Sci. 2022 Dec 30;24(1):. (PMID: 36614089)
Int J Oncol. 2014 Jun;44(6):1813-9. (PMID: 24718924)
Oncotarget. 2014 Dec 15;5(23):12358-70. (PMID: 25481044)
Am J Hematol. 2017 Jul;92(7):674-682. (PMID: 28370157)
J Urol. 2012 Dec;188(6):2410-8. (PMID: 23088964)
Cancers (Basel). 2022 Feb 12;14(4):. (PMID: 35205670)
Proc Natl Acad Sci U S A. 1990 Sep;87(18):7071-5. (PMID: 2205851)
Blood. 2008 Sep 15;112(6):2489-99. (PMID: 18565852)
Nat Methods. 2012 Jul;9(7):671-5. (PMID: 22930834)
Leukemia. 2008 Apr;22(4):708-22. (PMID: 18337766)
Bio Protoc. 2013 Mar 20;3(6):. (PMID: 27430005)
FEBS Lett. 2017 Sep;591(17):2648-2660. (PMID: 28696498)
Biochem Biophys Res Commun. 2012 Aug 24;425(2):357-62. (PMID: 22842575)
PLoS One. 2014 Mar 07;9(3):e90992. (PMID: 24608798)
Clin Cancer Res. 2000 Sep;6(9):3719-28. (PMID: 10999766)
J Clin Oncol. 2004 Jun 1;22(11):2108-21. (PMID: 15169797)
Blood. 2003 Feb 15;101(4):1530-4. (PMID: 12393500)
Neoplasia. 2021 Jan;23(1):80-98. (PMID: 33246310)
Autophagy. 2010 Feb;6(2):292-3. (PMID: 20087063)
Antioxidants (Basel). 2021 Apr 22;10(5):. (PMID: 33922139)
J Cell Mol Med. 2020 Aug;24(16):9428-9438. (PMID: 32628811)
Mol Cancer Ther. 2006 Mar;5(3):665-75. (PMID: 16546981)
- الرقم المعرف:
69G8BD63PP (Bortezomib)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
0 (Proteasome Inhibitors)
0 (Ubiquitins)
0 (Antineoplastic Agents)
- الموضوع:
Date Created: 20240227 Date Completed: 20240229 Latest Revision: 20240229
- الموضوع:
20240229
- الرقم المعرف:
PMC10898778
- الرقم المعرف:
10.1371/journal.pone.0289904
- الرقم المعرف:
38412186
No Comments.