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Risk factors for post-cerebral infarction cognitive dysfunction in older adults: a retrospective study.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968555 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2377 (Electronic) Linking ISSN: 14712377 NLM ISO Abbreviation: BMC Neurol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2001-
    • الموضوع:
      Diabetes Mellitus, Type 2*/complications ; Cognitive Dysfunction*/etiology ; Cognitive Dysfunction*/complications; Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Retrospective Studies ; Risk Factors ; Cerebral Infarction/complications ; Cerebral Infarction/epidemiology ; Cognition ; Bilirubin
    • نبذة مختصرة :
      Objective: Our research aims to elucidate the significance of type 2 diabetes (T2D) and provides an insight into a novel risk model for post-cerebral infarction cognitive dysfunction (PCICD).
      Methods: Our study recruited inpatients hospitalized with cerebral infarction in Xijing hospital, who underwent cognitive assessment of Mini-Mental State Examination (MMSE) from January 2010 to December 2021. Cognitive status was dichotomized into normal cognition and cognitive impairment. Collected data referred to Demographic Features, Clinical Diseases, scale tests, fluid biomarkers involving inflammation, coagulation function, hepatorenal function, lipid and glycemic management.
      Results: In our pooled dataset from 924 eligible patients, we included 353 in the final analysis (age range 65-91; 30.31% female). Multivariate logistic regression analysis was performed to show that Rural Areas (OR = 1.976, 95%CI = 1.111-3.515, P = 0.020), T2D (OR = 2.125, 95%CI = 1.267-3.563, P = 0.004), Direct Bilirubin (OR = 0.388, 95%CI = 0.196-0.769, P = 0.007), Severity of Dependence in terms of Barthel Index (OR = 1.708, 95%CI = 1.193-2.445, P = 0.003) that were independently associated with PCICD, constituting a model with optimal predictive efficiency.
      Conclusion: To the best of our knowledge, this study provides a practicable map of strategical predictors to robustly identify cognitive dysfunction at risk of post-cerebral infarction for clinicians in a broad sense. Of note, our findings support that the decline in serum direct bilirubin (DBil) concentration is linked to protecting cognitive function.
      (© 2024. The Author(s).)
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    • Grant Information:
      2022SF160 Key Research and Development Projects of Shaanxi Province; 81370928 Innovative Research Group Project of the National Natural Science Foundation of China; XJZT18ML79 Construct Program of the Key Discipline in Xijing Hospital; 2022MPPY006 Nursery Project in Tangdu Hospital
    • Contributed Indexing:
      Keywords: Cerebral infarction; Cognitive dysfunction; Older adults; Risk factors; Stroke; Type 2 diabetes
    • الرقم المعرف:
      RFM9X3LJ49 (Bilirubin)
    • الموضوع:
      Date Created: 20240220 Date Completed: 20240222 Latest Revision: 20240224
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC10877785
    • الرقم المعرف:
      10.1186/s12883-024-03574-7
    • الرقم المعرف:
      38378548