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Effect of intermittent subchronic MK-801 administration on dopamine synthesis capacity and responsiveness in the prefrontal cortex.
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- معلومة اضافية
- المصدر:
Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101719700 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2574-173X (Electronic) Linking ISSN: 2574173X NLM ISO Abbreviation: Neuropsychopharmacol Rep Subsets: MEDLINE
- بيانات النشر:
Original Publication: [Hoboken, NJ] : John Wiley & Sons, Inc., [2018]-
- الموضوع:
- نبذة مختصرة :
Aim: The therapeutic potential of N-methyl-D-aspartate glutamate receptor (NMDAR) antagonists, particularly ketamine, in mood disorders, is linked to their modulation of dopamine dynamics in the medial prefrontal cortex (mPFC). However, conflicting effects of distinct NMDAR antagonists, like ketamine and phencyclidine, on mPFC dopamine levels stem from variances in their receptor affinity profiles. This study investigates the impact of intermittent subchronic administration of an NMDAR antagonist on dopamine synthesis capacity and responsiveness within the mPFC, focusing on Dizocilpine (MK-801), a highly selective NMDAR antagonist.
Methods: In vivo microdialysis and high-performance liquid chromatography assessed extracellular dopamine levels in the mPFC following subchronic MK-801 treatment. Locomotor activity was measured using a computed video tracking system.
Results: Intermittent subchronic MK-801 administration, followed by a 24-h withdrawal, preserved both dopamine synthesis capacity and responsiveness to MK-801 challenge in the mPFC. However, altered locomotor activity was observed, deviating from previous findings indicating impaired dopamine synthesis and responsiveness in the mPFC with twice-daily subchronic NMDAR antagonist treatment.
Conclusion: These findings offer crucial biochemical insights into the diverse impacts of NMDAR antagonists on dopamine dynamics and the distinct therapeutic mechanisms associated with ketamine in depression treatment. However, further investigation is imperative to pinpoint potential inconsistencies stemming from variances in drug type, dosage, or administration frequency.
(© 2024 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology.)
- References:
BMC Anesthesiol. 2020 Jun 15;20(1):149. (PMID: 32539742)
Neuropharmacology. 2007 Sep;53(3):379-89. (PMID: 17632185)
Brain Res. 1997 Jun 13;759(2):205-12. (PMID: 9221938)
Neuropsychopharmacol Rep. 2024 Jun;44(2):333-341. (PMID: 38376999)
Psychopharmacology (Berl). 2015 Nov;232(21-22):4085-97. (PMID: 25943167)
Neuropsychopharmacology. 2005 Oct;30(10):1861-9. (PMID: 15841110)
J Psychopharmacol. 2017 Jun;31(6):660-666. (PMID: 28441905)
Pharmacol Biochem Behav. 1990 Apr;35(4):815-21. (PMID: 2161108)
Arch Gen Psychiatry. 2006 Aug;63(8):856-64. (PMID: 16894061)
J Affect Disord. 2022 Jul 1;308:289-297. (PMID: 35429529)
Psychopharmacology (Berl). 2008 Oct;200(2):281-90. (PMID: 18594799)
Mol Psychiatry. 2018 Jan;23(1):59-69. (PMID: 28972576)
J Physiol. 1991 Jan;432:483-508. (PMID: 1832184)
Psychiatry Res. 2006 Oct 30;147(2-3):243-8. (PMID: 16952448)
Brain Res. 1993 Oct 22;625(2):333-6. (PMID: 8275316)
Neurosci Lett. 1998 Dec 24;258(3):175-8. (PMID: 9885959)
Cereb Cortex. 2001 May;11(5):452-62. (PMID: 11313297)
Science. 1997 Aug 15;277(5328):953-5. (PMID: 9252326)
Psychopharmacology (Berl). 1992;108(3):271-5. (PMID: 1523278)
Psychopharmacology (Berl). 2005 Jul;180(2):366-76. (PMID: 15856186)
Pharmacol Biochem Behav. 2008 Nov;91(1):170-5. (PMID: 18675292)
Life Sci. 2006 Apr 4;78(19):2172-8. (PMID: 16280137)
J Am Acad Child Adolesc Psychiatry. 2012 Apr;51(4):404-11. (PMID: 22449646)
J Affect Disord. 2020 Dec 1;277:831-841. (PMID: 33065824)
Biol Psychiatry. 2013 Apr 1;73(7):639-45. (PMID: 23228328)
Neuropharmacology. 2017 Jul 15;121:195-203. (PMID: 28479397)
Biol Psychiatry. 2000 Feb 15;47(4):351-4. (PMID: 10686270)
Psychopharmacology (Berl). 2005 Dec;183(2):190-200. (PMID: 16220338)
Elife. 2021 Apr 27;10:. (PMID: 33904412)
Prog Neuropsychopharmacol Biol Psychiatry. 2022 Aug 30;118:110575. (PMID: 35568275)
Nat Rev Neurosci. 2016 Aug;17(8):524-32. (PMID: 27256556)
J Pharmacol Exp Ther. 1993 Jan;264(1):249-55. (PMID: 8093727)
Arch Gen Psychiatry. 1994 Mar;51(3):199-214. (PMID: 8122957)
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1661-4. (PMID: 11818555)
Neuropsychopharmacology. 2004 Feb;29(2):300-7. (PMID: 14560321)
Eur J Pharmacol. 1992 Dec 8;229(1):75-82. (PMID: 1361915)
Behav Brain Res. 2009 Aug 12;201(2):239-43. (PMID: 19428640)
- Grant Information:
20K03483 Japan Society for the Promotion of Science
- Contributed Indexing:
Keywords: MK‐801; NMDAR antagonists; dopamine; medial prefrontal cortex; subchronic
- الرقم المعرف:
6LR8C1B66Q (Dizocilpine Maleate)
VTD58H1Z2X (Dopamine)
0 (Excitatory Amino Acid Antagonists)
0 (Receptors, N-Methyl-D-Aspartate)
- الموضوع:
Date Created: 20240220 Date Completed: 20240603 Latest Revision: 20240605
- الموضوع:
20240605
- الرقم المعرف:
PMC11144610
- الرقم المعرف:
10.1002/npr2.12420
- الرقم المعرف:
38376999
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