Adolescent social isolation increases binge-like alcohol drinking in male but not female high-alcohol-preferring mice.

Publisher: Oxford University Press Country of Publication: England NLM ID: 8310684 Publication Model: Print Cited Medium: Internet ISSN: 1464-3502 (Electronic) Linking ISSN: 07350414 NLM ISO Abbreviation: Alcohol Alcohol Subsets: MEDLINE

Publication: <2003- > : Oxford : Oxford University Press
Original Publication: Oxford ; New York : Pergamon Press, c1983-

Alcohol Drinking* ; Binge Drinking*/complications; Mice ; Male ; Female ; Animals ; Ethanol/pharmacology ; Social Isolation ; Corticosterone ; Genetic Predisposition to Disease ; Mice, Inbred C57BL

Aims: This study examined how adolescent social isolation affects adult binge-like alcohol drinking and stress-axis function, via basal levels of circulating corticosterone (CORT), in male and female mice with a genetic predisposition toward high alcohol preference (HAP).
Methods: Male and female HAP2 mice were randomly assigned to a group-housed or social isolation (ISO) group. Social isolation began at postnatal Days 40-42 and lasted for 21 days prior to assessment of binge-like alcohol drinking using a 4-day drinking-in-the-dark (DID) procedure. Blood samples to assess basal CORT were taken 6 days after social isolation ended and 24 h before DID started, and again 60 h after DID ended, during the light portion of the light cycle.
Results: Adolescent social isolation increased adult binge-like alcohol drinking in male but not female mice. All groups showed significantly lower CORT after DID compared to before DID. Pearson bivariate correlation coefficients between the first 2 h of grams-per-kilogram alcohol intake on Day 4 and CORT levels indicated a significant positive correlation in ISO males only after DID and negative correlations in ISO females before and after DID.
Conclusions: These findings demonstrate that adolescent social isolation increased binge-like alcohol drinking in male but not female adult HAP2 mice. Stress-axis adaptations in male HAP2 mice may be associated with the social-isolation-induced increase in binge-like alcohol drinking.
(© The Author(s) 2024. Medical Council on Alcohol and Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

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P60 07611 United States AA NIAAA NIH HHS

Keywords: adolescent; corticosterone; ethanol; mouse; preference; stress

3K9958V90M (Ethanol)
W980KJ009P (Corticosterone)

Date Created: 20240216 Date Completed: 20240219 Latest Revision: 20250215

20250215

PMC10873267

10.1093/alcalc/agae006

38364318