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Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study.

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  • معلومة اضافية
    • المصدر:
      Publisher: Taylor & Francis Country of Publication: England NLM ID: 100892202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-8305 (Electronic) Linking ISSN: 1028415X NLM ISO Abbreviation: Nutr Neurosci Subsets: MEDLINE
    • بيانات النشر:
      Publication: 2016- : Abingdon : Taylor & Francis
      Original Publication: [Amsterdam?] : Harwood Academic Publishers : Overseas Publishers Association [distributor], c1998-
    • الموضوع:
      Alzheimer Disease*/genetics ; Alzheimer Disease*/epidemiology ; Mendelian Randomization Analysis* ; Fruit* ; Genome-Wide Association Study* ; Diet* ; Vegetables*; Humans ; Edible Grain ; Polymorphism, Single Nucleotide
    • نبذة مختصرة :
      Background: Alzheimer's disease (AD) is a degenerative disease of the nervous system. Observational studies have found an association between plant food intake and AD. However, it is unclear whether this association is influenced by confounding factors. We aimed to explore the causal relationship between plant-based diet and the risk of AD using two-sample Mendelian randomization.
      Materials and Methods: We obtained datasets of exposure from the IEU Open GWAS project, including dried fruit intake, fresh fruit intake, raw vegetable intake, cooked vegetable intake, and cereal intake. The summary data for AD were obtained from a large GWAS meta-analysis containing 71,880 cases and 383,378 controls.
      Results: Increased intake of dried fruits was associated with a reduced risk of AD (IVW: OR = 0.88, 95CI = 0.82-0.95). No causal association was found between the intake of other foods and AD.
      Conclusion: This MR study suggests that genetically predicted increased intake of dried fruits is a causal protective factor for AD.
    • Contributed Indexing:
      Keywords: Alzheimer's disease; Diet; Mendelian randomization; causal association; dried fruit; foods‌; genome-wide association study; single nucleotide polymorphisms‌
    • الموضوع:
      Date Created: 20240213 Date Completed: 20241101 Latest Revision: 20241101
    • الموضوع:
      20241101
    • الرقم المعرف:
      10.1080/1028415X.2024.2312685
    • الرقم المعرف:
      38347678