Genetic Association between the Risk of Dental Caries and MTR Gene Polymorphism in Chinese Children.

Publisher: Tohoku University Medical Library Country of Publication: Japan NLM ID: 0417355 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-3329 (Electronic) Linking ISSN: 00408727 NLM ISO Abbreviation: Tohoku J Exp Med Subsets: MEDLINE

Original Publication: Sendai : Tohoku University Medical Library

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase*/genetics ; Dental Caries*/genetics ; Genetic Predisposition to Disease*; Child ; Child, Preschool ; Female ; Humans ; Male ; Case-Control Studies ; China ; East Asian People/genetics ; Gene Frequency/genetics ; Genetic Association Studies ; Logistic Models ; Odds Ratio ; Polymorphism, Single Nucleotide ; Risk Factors

Early childhood caries (ECC) is common in children. Little is known about the genetic association of the methionine synthesis reductase (MTRR) gene rs1801394 and methionine synthetase (MTR) gene rs1805087 polymorphisms with ECC, which was examined in the Chinese Han population. Genotyping was performed using the buccal mucosa from 150 normal and 150 ECC children. For genotype and allele distribution comparison, Chi-square test and multiple logistic regression analysis were performed. The odd ratio (OR) and 95% confidence interval (CI) were calculated. MTR gene rs1805087 AG genotype distribution in the ECC group was clearly different from the control group (P = 0.029), and the ECC risk in cases with AG genotype was 0.525 times lower than those carrying AA genotype (95% CI = 0.292-0.942). Logistic regression analysis after adjustment for other clinical indicators determined that the MTR gene rs1805087 AG genotype was still strongly associated with susceptibility to ECC (OR = 0.499, 95% CI = 0.273-0.913, P = 0.024). Significant association was also seen for sugary food intakes (OR = 1.965, 95% CI = 1.162-3.321, P = 0.012), tooth brushing (OR = 0.569, 95% CI = 0.356-0.924, P = 0.023) and sex (OR = 0.562, 95% CI = 0.349-0.907, P = 0.018) with ECC risk. No notable genetic association was found between MTRR gene rs1801394 polymorphism and ECC risk. MTR gene rs1805087 polymorphism may aggrandize the susceptibility to ECC, and AA genotype appeared to be a dangerous element for the development of ECC.

Keywords: Chinese Han population; MTR gene; early childhood caries; genetic predisposition

EC 2.1.1.13 (5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase)
EC 2.1.1.13. (MTR protein, human)

Date Created: 20240207 Date Completed: 20240602 Latest Revision: 20240612

20240612

10.1620/tjem.2024.J011

38325832