Bisphenol A and its alternatives bisphenol S and F exposure with serum uric acid levels, hyperuricemia, and gout prevalence among US adults: a nationally representative cross-sectional study.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Hyperuricemia*/chemically induced ; Hyperuricemia*/epidemiology ; Gout*/epidemiology ; Phenols* ; Sulfones*; Adult ; Humans ; Male ; Female ; Uric Acid ; Cross-Sectional Studies ; Prevalence ; Nutrition Surveys ; Benzhydryl Compounds

Background: Recent studies suggested inconclusive associations between bisphenols exposure and hyperuricemia risk. Our objective was to assess the potential association of bisphenol A (BPA) and its substitutes bisphenol S and F (BPS and BPF) exposure with serum uric acid (SUA) levels, hyperuricemia, and gout prevalence among US adults within the NHANES 2013-2016 datasets.
Methods: Multivariable linear and logistic regression models were used to explore the associations of urinary bisphenols concentrations with SUA levels, hyperuricemia, and gout prevalence, in total population and different sex groups. The restricted cubic spline (RCS) model was used to explore the dose-response relationship.
Results: In total population, doubling of urinary BPS and ∑BPs concentrations showed associations with an increase of 2.64 μmol/L (95% CI: 0.54, 4.74) and 3.29 μmol/L (95% CI: 0.59, 5.99) in SUA levels, respectively. The RCS model indicated a significantly "J"-shaped dose-response relationship between BPS exposure and SUA levels. Compared to the reference group of urinary BPS, males in the highest quartile displayed a 13.06 μmol/L (95% CI: 0.75, 25.37) rise in SUA levels. For females, doubling of urinary BPS concentrations was associated with a 3.30 μmol/L (95% CI: 0.53, 6.07) increase in SUA levels, with a significant linear dose-response relationship. In total population, doubling of urinary BPA concentrations showed a 1.05-fold (95% CI: 0.97, 1.14) adjusted risk of having hyperuricemia, with an inverted "U" curve. Doubling of urinary ∑BPs concentrations was associated with a 1.05-fold (95% CI: 0.96, 1.14) adjusted risk of hyperuricemia in total population, with a significant monotonic dose-response relationship. In females, doubling of urinary BPS concentrations was associated with a 1.45-fold (95% CI: 1.01, 2.08) adjusted increased risk of having gout, with a "J" shaped relationship.
Conclusions: BPA and BPS exposure to some extent were associated with elevated SUA levels and increased risk of hyperuricemia, with different dose-response relationships and sex differences.
(© 2024. The Author(s).)

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ZR2021QH249 Shandong Provincial Natural Science Foundation; JYHL2021MS20 Research Fund for the Lin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical University; 2021D01A02 Natural Science Foundation of Xinjiang Uygur Autonomous Region; 2021D01A02 Natural Science Foundation of Xinjiang Uygur Autonomous Region; 2021-BS-006 PhD Research Foundation of Affiliated Hospital of Jining Medical University; 2022YXNS031 2022 key research and development program of Jining Science and Technology Bureau

Keywords: Bisphenol; Gout; Hyperuricemia; NHANES; Uric acid

268B43MJ25 (Uric Acid)
MLT3645I99 (bisphenol A)
0 (bisphenol F)
0 (Benzhydryl Compounds)
80-09-1 (bis(4-hydroxyphenyl)sulfone)
0 (Phenols)
0 (Sulfones)

Date Created: 20240205 Date Completed: 20240207 Latest Revision: 20240210

20240210

PMC10840165

10.1186/s12889-024-17883-6

38317153