Enzymes for dermatological use.

Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9301549 Publication Model: Print Cited Medium: Internet ISSN: 1600-0625 (Electronic) Linking ISSN: 09066705 NLM ISO Abbreviation: Exp Dermatol Subsets: MEDLINE

Original Publication: Copenhagen : Munksgaard, c1992-

Skin Diseases*/therapy ; Cosmetics*/pharmacology; Humans ; Ultraviolet Rays/adverse effects ; Skin ; Sunlight/adverse effects

Skin is the ultimate barrier between body and environment and prevents water loss and penetration of pathogens and toxins. Internal and external stressors, such as ultraviolet radiation (UVR), can damage skin integrity and lead to disorders. Therefore, skin health and skin ageing are important concerns and increased research from cosmetic and pharmaceutical sectors aims to improve skin conditions and provide new anti-ageing treatments. Biomolecules, compared to low molecular weight drugs and cosmetic ingredients, can offer high levels of specificity. Topically applied enzymes have been investigated to treat the adverse effects of sunlight, pollution and other external agents. Enzymes, with a diverse range of targets, present potential for dermatological use such as antioxidant enzymes, proteases and repairing enzymes. In this review, we discuss enzymes for dermatological applications and the challenges associated in this growing field.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

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extranjero/2020 - 72210489 Agencia Nacional de Investigación y Desarrollo; CAPES-Brazil process number: 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; # 309953/2020-0 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 2020/08129-6 2022/01138-5 Fundação de Amparo à Pesquisa do Estado de São Paulo

Keywords: DNA repair enzymes; antioxidant enzymes; enzymes for topical use; proteases

0 (Cosmetics)

Date Created: 20240129 Date Completed: 20240130 Latest Revision: 20240206

20250114

10.1111/exd.15008

38284197