The effect of electrical stimulation on skin vulnerability to irritants.

Publisher: Blackwell Country of Publication: England NLM ID: 9504453 Publication Model: Print Cited Medium: Internet ISSN: 1600-0846 (Electronic) Linking ISSN: 0909752X NLM ISO Abbreviation: Skin Res Technol Subsets: MEDLINE

Publication: <1998-> : Oxford : Blackwell
Original Publication: Copenhagen, Denmark ; Cambridge, MA : Munksgaard, c1995-

Irritants*/pharmacology ; Dermatitis, Irritant*/etiology; Male ; Humans ; Water Loss, Insensible ; Skin ; Sodium Dodecyl Sulfate/pharmacology ; Erythema

Purpose: Electrical stimulation (ES) is a widely used technique in the medical field for various purposes. The effect of ES on several skin properties has been investigated; however, its effect on skin vulnerability to irritants remains unknown. This study aimed to investigate the effects of ES application on skin vulnerability to external irritants.
Materials and Methods: An experimental study on 12 healthy male subjects (Mean ± SD, 22.9 ± 3.6 years) who completed the study. The subjects were free of skin abnormalities in the volar aspect of both forearms. Three areas were allocated to each forearm and marked as areas 1, 2, and A in the treated forearm, and areas 3, 4, and B in the control forearm. ES was applied to the volar aspect of the treated forearm for 30 min three times a week, for 2 weeks. The effect of ES on skin vulnerability was investigated using 5% and 0.5% sodium lauryl sulfate (SLS) patches applied to both treated and control forearms. The skin response to irritants was evaluated using transepidermal water loss (TEWL) and a visual erythema score 24 h after patch removal.
Results: Compared to the control forearm, ES increased skin permeability and erythema in response to external irritants (SLS), as measured by the visual analog score (Z = 2.75, p = 0.006) and TEWL (p < 0.05), respectively.
Conclusions: ES escalates skin reactions to low concentrations of irritant substances, such as SLS, in the area between the two electrodes. This emphasizes the use of this substance, and similar irritants should be avoided in areas treated with ES.
(© 2024 The Authors. Skin Research and Technology published by John Wiley & Sons Ltd.)

Environ Health Insights. 2015 Nov 17;9:27-32. (PMID: 26617461)
J Back Musculoskelet Rehabil. 2021;34(5):895-902. (PMID: 34092603)
Skin Res Technol. 2024 Feb;30(2):e13591. (PMID: 38279544)
J Sport Rehabil. 2021 Jan 13;30(5):744-753. (PMID: 33440342)
Pharmaceutics. 2020 Jul 20;12(7):. (PMID: 32698388)
J Dermatol. 2021 Feb;48(2):e74-e75. (PMID: 33035368)
J Med Eng Technol. 2006 Nov-Dec;30(6):368-81. (PMID: 17060165)
J Cosmet Sci. 2005 Sep-Oct;56(5):311-21. (PMID: 16258697)
Contact Dermatitis. 1990 Mar;22(3):164-78. (PMID: 2335090)
J Dermatolog Treat. 2020 Dec;31(8):846-849. (PMID: 31418608)
Dermatology. 1999;199(3):281. (PMID: 10592420)
J Med Eng Technol. 2009;33(8):663-9. (PMID: 19848861)
Int J Pharm. 2010 Jan 15;384(1-2):73-7. (PMID: 19799976)
Int J Cardiol Heart Vasc. 2023 Mar 28;45:101189. (PMID: 37025482)
Contact Dermatitis. 2017 Dec;77(6):409-412. (PMID: 29164695)
Physiother Res Int. 2013 Sep;18(3):157-66. (PMID: 23165924)
Contact Dermatitis. 2000 Mar;42(3):172-3. (PMID: 10727175)
Skin Res Technol. 2007 Nov;13(4):390-8. (PMID: 17908190)
N Engl J Med. 1990 Jun 7;322(23):1627-34. (PMID: 2140432)
J Sports Sci Med. 2005 Mar 01;4(1):66-75. (PMID: 24431963)
Acta Mech Sin. 2021;37(12):1843-1871. (PMID: 33584001)
Int J Low Extrem Wounds. 2020 Sep;19(3):242-250. (PMID: 32000553)
Int J Toxicol. 2010 May;29(3 Suppl):115S-32S. (PMID: 20448271)
Front Physiol. 2021 Nov 19;12:756200. (PMID: 34867459)
Contact Dermatitis. 1997 Aug;37(2):53-69. (PMID: 9285167)
Contact Dermatitis. 2020 Oct;83(4):326-328. (PMID: 32432362)
Contact Dermatitis. 2010 Mar;62(3):189-90. (PMID: 20565511)
Gac Med Mex. 2020;156(5):418-423. (PMID: 33372931)
Acta Derm Venereol. 2014 Nov;94(6):640-4. (PMID: 24531413)

Keywords: electrical stimulation; physical therapy; skin irritation; skin vulnerability; transepidermal water loss

0 (Irritants)
368GB5141J (Sodium Dodecyl Sulfate)

Date Created: 20240127 Date Completed: 20240129 Latest Revision: 20241023

20241023

PMC10818122

10.1111/srt.13591

38279544