Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Study protocol: infectious diseases consortium (I3D) for study on integrated and innovative approaches for management of respiratory infections: respiratory infections research and outcome study (RESPIRO).

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2001-
    • الموضوع:
      Respiratory Tract Infections* ; Communicable Diseases* ; Pneumonia*; Adult ; Humans ; Prospective Studies ; Outcome Assessment, Health Care ; Observational Studies as Topic
    • نبذة مختصرة :
      Background: Community-acquired respiratory infections are a leading cause of illness and death globally. The aetiologies of community-acquired pneumonia remain poorly defined. The RESPIRO study is an ongoing prospective observational cohort study aimed at developing pragmatic logistical and analytic platforms to accurately identify the causes of moderate-to-severe community-acquired pneumonia in adults and understand the factors influencing disease caused by individual pathogens. The study is currently underway in Singapore and has plans for expansion into the broader region.
      Methods: RESPIRO is being conducted at three major tertiary hospitals in Singapore. Adults hospitalised with acute community-acquired pneumonia or lower respiratory tract infections, based on established clinical, laboratory and radiological criteria, will be recruited. Over the course of the illness, clinical data and biological samples will be collected longitudinally and stored in a biorepository for future analysis.
      Discussion: The RESPIRO study is designed to be hypothesis generating, complementary to and easily integrated with other research projects and clinical trials. The detailed clinical database and biorepository will yield insights into the epidemiology and outcomes of community-acquired lower respiratory tract infections in Singapore and the surrounding region and offers the opportunity to deeply characterise the microbiology and immunopathology of community-acquired pneumonia.
      (© 2024. The Author(s).)
    • References:
      Int J Epidemiol. 2020 Jun 1;49(3):717-726. (PMID: 32086938)
      Clin Infect Dis. 2021 Jun 15;72(12):2225-2240. (PMID: 33104186)
      JAMA. 2020 Apr 21;323(15):1488-1494. (PMID: 32125362)
      N Engl J Med. 2015 Jul 30;373(5):415-27. (PMID: 26172429)
      N Engl J Med. 2021 Feb 25;384(8):693-704. (PMID: 32678530)
      N Engl J Med. 2015 Feb 26;372(9):835-45. (PMID: 25714161)
      Int J Antimicrob Agents. 2008 Feb;31(2):107-14. (PMID: 18162378)
      Perspect Med Virol. 2006;16:325-343. (PMID: 32287587)
      N Engl J Med. 2020 Oct 22;383(17):e97. (PMID: 32905667)
    • Grant Information:
      OFLCG19May-0034 National Medical Research Council; OFLCG19May-0034 National Medical Research Council; OFLCG19May-0034 National Medical Research Council; OFLCG19May-0034 National Medical Research Council
    • Contributed Indexing:
      Keywords: Community-acquired pneumonia; Epidemiology; Pathogenesis; Study protocol
    • الموضوع:
      Date Created: 20240123 Date Completed: 20240125 Latest Revision: 20240126
    • الموضوع:
      20240126
    • الرقم المعرف:
      PMC10807062
    • الرقم المعرف:
      10.1186/s12879-023-08795-8
    • الرقم المعرف:
      38262970