Severe Post-COVID-19 Condition after Mild Infection: Physical and Mental Health Eight Months Post Infection: A Cross-Sectional Study.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE

Original Publication: Basel : MDPI, c2004-

Mental Health* ; COVID-19*/epidemiology; Humans ; Female ; Male ; Cross-Sectional Studies ; Quality of Life ; Post-Acute COVID-19 Syndrome ; Chronic Disease ; Fatigue/epidemiology ; Fatigue/etiology

Severe acute COVID-19 infections requiring intensive care treatment are reported risk factors for the development of post-COVID-19 conditions. However, there are also individuals suffering from post-COVID-19 symptoms after mild infections. Therefore, we aimed to describe and compare the health status of patients who were initially not hospitalized and patients after critical illness due to COVID-19. The outcome measures included health-related quality of life (EQ-5D-5L, visual analogue scale (VAS)); mental health (hospital anxiety and depression scale (HADS)); general disability (WHODAS-12); and fatigue (Fatigue-Severity-Scale-7). Individuals were recruited at Schoen Clinic Bad Aibling, Germany. A total of 52 non-hospitalized individuals (47 ± 15 years, 64% female, median 214 days post-infection) and 75 hospitalized individuals (61 ± 12 years, 29% female, 235 days post-infection) were analyzed. The non-hospitalized individuals had more fatigue (87%) and anxiety (69%) and a decreased health-related quality of life (VAS 47 ± 20) compared to the hospitalized persons (fatigue 45%, anxiety 43%, VAS 57 ± 21; p < 0.010). Severe disability was observed in one third of each group. A decreased quality of life and disability were more pronounced in the females of both groups. After adjusting for confounding, hospitalization did not predict the burden of symptoms. This indicates that persons with post-COVID-19 conditions require follow-up services and treatments, independent of the severity of the acute infection.

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2021_EKEA.78 Else Kröner-Fresenius-Stiftung; LGL-GE8_1/2021 Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit

Keywords: COVID-19; critical illness; fatigue; hospitalization; intensive care units; mental health; neurological rehabilitation; patient reported outcome measures; post-acute COVID-19 syndrome; quality of life

Date Created: 20240122 Date Completed: 20240123 Latest Revision: 20241023

20241023

PMC10815598

10.3390/ijerph21010021

38248486