Identification of a vascular invasion-related signature based on lncRNA pairs for predicting prognosis in hepatocellular carcinoma.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

RNA, Long Noncoding*/genetics ; Carcinoma, Hepatocellular*/genetics ; Liver Neoplasms*/genetics; Humans ; Prognosis ; Algorithms

Objectives: Most signatures are constructed on the basis of RNA or protein expression levels. The value of vascular invasion-related signatures based on lncRNA pairs, regardless of their specific expression level in hepatocellular carcinoma (HCC), is not yet clear.
Methods: Vascular invasion-related differentially expressed lncRNA (DElncRNA) pairs were identified with a two-lncRNA combination strategy by using a novel modeling algorithm. Based on the optimal cutoff value of the ROC curve, patients with HCC were classified into high- and low-risk subgroups. We used KM survival analysis to evaluate the overall survival rate of patients in the high- and low-risk subgroups. The independent indicators of survival were identified using univariate and multivariate Cox analyses.
Results: Five pairs of vascular invasion-related DElncRNAs were selected to develop a predictive model for HCC. High-risk subgroups were closely associated with aggressive clinicopathological characteristics and genes, chemotherapeutic sensitivity, and highly expressed immune checkpoint inhibitors.
Conclusions: We identified a signature composed of 5 pairs of vascular invasion-related lncRNAs that does not require absolute expression levels of lncRNAs and shows promising clinical predictive value for HCC prognosis. This predictive model provides deep insight into the value of vascular invasion-related lncRNAs in prognosis.
(© 2024. The Author(s).)

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19JCYBJC25800 Nature Science Foundation of Tianjin; No. 20JCZXJC00160 Beijing,Tianjin and Hebei basic research cooperation project

Keywords: HCC; Prognosis; Vascular invasion; lncRNA pairs

0 (RNA, Long Noncoding)

Date Created: 20240114 Date Completed: 20240116 Latest Revision: 20240117

20240117

PMC10788995

10.1186/s12876-023-03118-2

38221614