Adult stem cells in the eye: Identification, characterisation, and therapeutic application in ocular regeneration - A review.

Publisher: Wiley-Blackwell Pub. Asia Country of Publication: Australia NLM ID: 100896531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1442-9071 (Electronic) Linking ISSN: 14426404 NLM ISO Abbreviation: Clin Exp Ophthalmol Subsets: MEDLINE

Publication: Carlton, Vic. : Wiley-Blackwell Pub. Asia
Original Publication: Carlton, Vic. : Blackwell Science Asia, c2000-

Lens, Crystalline*/chemistry ; Eye Diseases*/therapy ; Adult Stem Cells*; Humans ; Child ; Retina ; Cornea ; Eyelids

Adult stem cells, present in various parts of the human body, are undifferentiated cells that can proliferate and differentiate to replace dying cells within tissues. Stem cells have specifically been identified in the cornea, trabecular meshwork, crystalline lens, iris, ciliary body, retina, choroid, sclera, conjunctiva, eyelid, lacrimal gland, and orbital fat. The identification of ocular stem cells broadens the potential therapeutic strategies for untreatable eye diseases. Currently, stem cell transplantation for corneal and conjunctival diseases remains the most common stem cell-based therapy in ocular clinical management. Lens epithelial stem cells have been applied in the treatment of paediatric cataracts. Several early-phase clinical trials for corneal and retinal regeneration using ocular stem cells are also underway. Extensive preclinical studies using ocular stem cells have been conducted, showing encouraging outcomes. Ocular stem cells currently demonstrate great promise in potential treatments of eye diseases. In this review, we focus on the identification, characterisation, and therapeutic application of adult stem cells in the eye.
(© 2024 The Authors. Clinical & Experimental Ophthalmology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists.)

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Keywords: adult stem cells; eye diseases; regeneration; stem cells; treatment

Date Created: 20240112 Date Completed: 20240311 Latest Revision: 20240311

20250114

10.1111/ceo.14309

38214071