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Neural substrates of cough control during coughing.

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  • معلومة اضافية
    • المصدر:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • الموضوع:
      Tomography, X-Ray Computed* ; Cough*; Male ; Humans ; Brain/diagnostic imaging ; Cerebellum ; Cerebral Cortex
    • نبذة مختصرة :
      Cough is known as a protective reflex to keep the airway free from harmful substances. Although brain activity during cough was previously examined mainly by functional magnetic resonance imaging (fMRI) with model analysis, this method does not capture real brain activity during cough. To obtain accurate measurements of brain activity during cough, we conducted whole-brain scans during different coughing tasks while correcting for head motion using a restraint-free positron emission tomography (PET) system. Twenty-four healthy right-handed males underwent multiple PET scans with [ 15 O]H 2 O. Four tasks were performed during scans: "resting"; "voluntary cough (VC)", which simply repeated spontaneous coughing; "induced cough (IC)", where participants coughed in response to an acid stimulus in the cough-inducing method with tartaric acid (CiTA); and "suppressed cough (SC)", where coughing was suppressed against CiTA. The whole brain analyses of motion-corrected data revealed that VC chiefly activated the cerebellum extending to pons. In contrast, CiTA-related tasks (IC and SC) activated the higher sensory regions of the cerebral cortex and associated brain regions. The present results suggest that brain activity during simple cough is controlled chiefly by infratentorial areas, whereas manipulating cough predominantly requires the higher sensory brain regions to allow top-down control of information from the periphery.
      (© 2024. The Author(s).)
    • References:
      Brain Struct Funct. 2015 Nov;220(6):3683-99. (PMID: 25158901)
      Arch Phys Med Rehabil. 1999 Feb;80(2):150-4. (PMID: 10025488)
      J Neurophysiol. 2019 Apr 1;121(4):1171-1182. (PMID: 30649977)
      Respir Med. 1993 Jul;87(5):379-82. (PMID: 8209058)
      Respir Physiol Neurobiol. 2006 Jul 28;152(3):243-54. (PMID: 16443402)
      Pulm Pharmacol Ther. 2011 Jun;24(3):308-11. (PMID: 21272659)
      Neuroimage. 2001 Dec;14(6):1370-86. (PMID: 11707093)
      Eur Respir J. 2019 Sep 19;54(3):. (PMID: 31248952)
      Pulm Pharmacol Ther. 2009 Apr;22(2):75-81. (PMID: 19284972)
      Neuroimage. 2005 Jul 1;26(3):839-51. (PMID: 15955494)
      Am J Respir Crit Care Med. 2007 Aug 15;176(4):327-32. (PMID: 17575093)
      J Physiol. 2010 Dec 1;588(Pt 23):4769-83. (PMID: 20937710)
      PLoS One. 2021 Jun 21;16(6):e0253060. (PMID: 34153070)
      J Neurosci. 2011 Feb 23;31(8):2948-58. (PMID: 21414916)
      Neuroscience. 2012 Apr 5;207:148-66. (PMID: 22306285)
      Pulm Pharmacol Ther. 2007;20(4):416-22. (PMID: 17189707)
      Neuroimage. 2021 Jan 1;224:117434. (PMID: 33039616)
      Nat Rev Dis Primers. 2022 Jun 30;8(1):45. (PMID: 35773287)
      Thorax. 2016 Apr;71(4):323-9. (PMID: 26860344)
      Dysphagia. 2022 Jun;37(3):629-635. (PMID: 33977315)
      Neuroimage. 2007 Aug 15;37(2):401-9. (PMID: 17574873)
      Brain Res. 1993 Mar 19;606(1):143-7. (PMID: 8461996)
      Phys Med Biol. 2017 Aug 18;62(17):7148-7166. (PMID: 28753133)
      Physiol Rev. 2016 Jul;96(3):975-1024. (PMID: 27279650)
      Eur Respir J. 2006 Jul;28(1):10-5. (PMID: 16816346)
      Hum Brain Mapp. 2014 Nov;35(11):5341-55. (PMID: 24862433)
      J Physiol. 2004 Jun 1;557(Pt 2):543-58. (PMID: 15004208)
      Cerebellum. 2014 Dec;13(6):767-76. (PMID: 25047686)
      eNeuro. 2020 Apr 9;7(2):. (PMID: 32060036)
      Respir Physiol. 1998 Oct;114(1):5-15. (PMID: 9858046)
      Pain. 2016 Jun;157(6):1279-1286. (PMID: 26871535)
      Neuroimage. 2009 Sep;47(3):1092-104. (PMID: 19460443)
      Annu Rev Neurosci. 2022 Jul 8;45:223-247. (PMID: 35259917)
      J Clin Neurophysiol. 2017 Jul;34(4):300-306. (PMID: 28644199)
      Pulm Pharmacol Ther. 2013 Oct;26(5):476-85. (PMID: 23831712)
      Respir Physiol Neurobiol. 2017 Sep;243:60-76. (PMID: 28549898)
      Odontology. 2014 Jan;102(1):76-80. (PMID: 23053789)
      Pain. 2005 Apr;114(3):397-407. (PMID: 15777865)
    • Grant Information:
      JP16H06402 [Willdynamics] Japan Society for the Promotion of Science
    • الموضوع:
      Date Created: 20240108 Date Completed: 20240110 Latest Revision: 20240111
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC10774348
    • الرقم المعرف:
      10.1038/s41598-024-51477-x
    • الرقم المعرف:
      38191647