Association between 14 candidate genes, PM2.5, and affective disorders: a study of the Taiwan Biobank.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968562 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2458 (Electronic) Linking ISSN: 14712458 NLM ISO Abbreviation: BMC Public Health Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Genetic Predisposition to Disease* ; Biological Specimen Banks*; Humans ; Retrospective Studies ; Longitudinal Studies ; Taiwan/epidemiology ; Calcium Channels, L-Type/genetics ; Mood Disorders ; Polymorphism, Single Nucleotide ; Particulate Matter/adverse effects ; Genome-Wide Association Study

Background: Most studies have focused on the risk factors, treatment, and care of affective psychosis, and several have reported a relationship between ambient air quality and this psychosis. Although an association has been reported between psychosis and genes, studies mainly explored the associations between one type of psychosis and one gene; few have identified genes related to affective psychosis. This study investigates the genetic and environmental factors of affective psychosis.
Methods: In this retrospective longitudinal study, 27 604 participants aged 30-70 were selected from Taiwan Biobank. The participants' propensity scores were calculated based on their demographic information, and propensity score matching was performed to divide the participants into an experimental (i.e., affective psychosis) and control group at a 1:5 ratio. Plink was used to analyze the major and minor types of gene expression related to affective psychosis, and PM 2.5 exposure was incorporated into the analyses.
Results: According to the generalized estimating equation analysis results, 8 single nucleotide polymorphisms (SNPs) belonging to the ANK3, BDNF, CACNA1C, and GRID1 genotypes were significantly correlated with depressive disorder (P < .001), with the majority belonging to the ANK3 and CACNA1C. A total of 5 SNPs belonging to the CACNA1C, GRID1, and SIRT1 genotypes were significantly correlated with bipolar disorder (P < .001), with the majority belonging to the CACNA1C. No significant correlation was identified between ambient air pollution and affective psychosis.
Conclusions: CACNA1C and GRID1 are common SNP genotypes for depressive disorder and bipolar disorder and should be considered associated with affective psychosis.
(© 2023. The Author(s).)

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MOST110-2410-H-039-001 Ministry of Science and Technology, Taiwan; CMU107-Z-04 China Medical University, Taiwan; ANHRF111-09 Tainan Municipal An-Nan Hospital

Keywords: Affective psychosis; Environmental risks; Gene; Genome-wide; Single nucleotide polymorphism (SNP)

0 (Calcium Channels, L-Type)
0 (Particulate Matter)

Date Created: 20231128 Date Completed: 20231129 Latest Revision: 20240116

20240117

PMC10683147

10.1186/s12889-023-16764-8

38012695