Targeted delivery of organic small-molecule photothermal materials with engineered extracellular vesicles for imaging-guided tumor photothermal therapy.

Publisher: BioMed Central Country of Publication: England NLM ID: 101152208 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-3155 (Electronic) Linking ISSN: 14773155 NLM ISO Abbreviation: J Nanobiotechnology Subsets: MEDLINE

Original Publication: London : BioMed Central, 2003-

Neoplasms*/diagnostic imaging ; Neoplasms*/drug therapy ; Nanoparticles* ; Photoacoustic Techniques*/methods; Humans ; Photothermal Therapy ; Phototherapy/methods ; Theranostic Nanomedicine/methods ; Coloring Agents ; Cell Line, Tumor

Imaging-guided photothermal therapy (PTT) for cancers recently gathered increasing focus thanks to its precise diagnosis and potent therapeutic effectiveness. Croconaine (CR) dyes demonstrate potential in expanding utility for near infrared (NIR) dyes in bio-imaging/theranostics. However, reports on CR dyes for PTT are scarce most likely due to the short of the efficacious delivery strategies to achieve specific accumulation in diseased tissues to induce PTT. Extracellular vesicles (EVs) are multifunctional nanoparticle systems that function as safe platform for disease theragnostics, which provide potential benefits in extensive biomedical applications. Here, we developed a novel delivery system for photothermal molecules based on a CR dye that exerts photothermal activity through CDH17 nanobody-engineered EVs. The formed CR@E8-EVs showed strong NIR absorption, excellent photothermal performance, good biological compatibility and superb active tumor-targeting capability. The CR@E8-EVs can not only visualize and feature the tumors through CR intrinsic property as a photoacoustic imaging (PAI) agent, but also effectively retard the tumor growth under laser irradiation to perform PTT. It is expected that the engineered EVs will become a novel delivery vehicle of small organic photothermal agents (SOPTAs) in future clinical PTT applications.
(© 2023. The Author(s).)

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2021A1515012164 the Basic and Applied Basic Research Foundation of GuangDong Province; GJHZ20200731095411034 the International Science and Technology Cooperation for Shenzhen Technology Innovation Plan; GJHZ20200731095411034 the International Science and Technology Cooperation for Shenzhen Technology Innovation Plan; No. 81972394 and 82272856 the National Natural Science Foundation of China

Keywords: Active tumor targeting; Croconaine dyes; Extracellular vesicles; Imaging-guided photothermal therapy; Small organic photothermal agents

0 (Coloring Agents)

Date Created: 20231123 Date Completed: 20231127 Latest Revision: 20231127

20231127

PMC10666357

10.1186/s12951-023-02133-5

37993888