Increased flow rate of hyperpolarized aqueous solution for dynamic nuclear polarization-enhanced magnetic resonance imaging achieved by an open Fabry-Pérot type microwave resonator.

Publisher: Copernicus Publications Country of Publication: Germany NLM ID: 101775538 Publication Model: eCollection Cited Medium: Internet ISSN: 2699-0016 (Electronic) Linking ISSN: 26990016 NLM ISO Abbreviation: Magn Reson (Gott) Subsets: PubMed not MEDLINE

Original Publication: [Gottingen, Germany] : Copernicus Publications, [2020]-

A continuous flow dynamic nuclear polarization (DNP) employing the Overhauser effect at ambient temperatures can be used among other methods to increase sensitivity of magnetic resonance imaging (MRI). The hyperpolarized state of water protons can be achieved by flowing aqueous liquid through a microwave resonator placed directly in the bore of a 1.5 T MRI magnet. Here we describe a new open Fabry-Pérot resonator as DNP polarizer, which exhibits a larger microwave exposure volume for the flowing liquid in comparison with a cylindrical TE 013 microwave cavity. The Fabry-Pérot resonator geometry was designed using quasi-optical theory and simulated by CST software. Performance of the new polarizer was tested by MRI DNP experiments on a TEMPOL aqueous solution using a blood-vessel phantom. The Fabry-Pérot resonator revealed a 2-fold larger DNP enhancement with a 4-fold increased flow rate compared to the cylindrical microwave resonator. This increased yield of hyperpolarized liquid allows MRI applications on larger target objects.
Competing Interests: The authors declare that they have no conflict of interest.
(Copyright: © 2020 Alexey Fedotov et al.)

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Date Created: 20231031 Latest Revision: 20231101

20240829

PMC10500708

10.5194/mr-1-275-2020

37904825