Pearl Powder Hybrid Bioactive Scaffolds from Microfluidic 3D Printing for Bone Regeneration.

Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

Original Publication: Weinheim : WILEY-VCH, [2014]-

Osteogenesis* ; Tissue Scaffolds*/chemistry; Rats ; Animals ; Vascular Endothelial Growth Factor A ; Microfluidics ; Bone Regeneration ; Printing, Three-Dimensional

The development of bioactive scaffolds by mimicking bone tissue extracellular matrix is promising for bone regeneration. Herein, inspired by the bone tissue composition, a novel pearl powder (PP) hybrid fish gelatin methacrylate (GelMa) hydrogel scaffold loaded with vascular endothelial growth factor (VEGF) for bone regeneration is presented. With the help of microfluidic-assisted 3D printing technology, the composition and structure of the hybrid scaffold can be accurately controlled to meet clinical requirements. The combination of fish skin GelMa and PP also endowed the hybrid scaffold with good biocompatibility, cell adhesion, and osteogenic differentiation ability. Moreover, the controlled release of VEGF enables the scaffold to promote angiogenesis. Thus, the bone regeneration in the proposed scaffolds could be accelerated under the synergic effect of osteogenesis and angiogenesis, which has been proved in the rat skull defect model. These features indicate that the PP hybrid scaffolds will be an ideal candidate for bone regeneration in clinical applications.
(© 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.)

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2020YFA0908200 National Key Research and Development Program of China; 82202670 National Natural Science Foundation of China; LQ23H060001 Zhejiang Provincial Natural Science Foundation of China; WIUCASQD2022001 Startup Fund of Wenzhou Institute, University of Chinese Academy of Sciences

Keywords: 3D printing; bone regeneration; growth factor; microfluidics; pearl powder

0 (Vascular Endothelial Growth Factor A)
0 (pearl powder)

Date Created: 20231023 Date Completed: 20231211 Latest Revision: 20240823

20250114

PMC10700190

10.1002/advs.202304190

37870197