Predictive Potential of Biomarkers of Intestinal Barrier Function for Therapeutic Management with Teduglutide in Patients with Short Bowel Syndrome.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Short Bowel Syndrome*/therapy; Humans ; Intestine, Small/pathology ; Glucagon-Like Peptide 2 ; Biomarkers ; Mannitol ; Gastrointestinal Agents/therapeutic use

Introduction: The human intestinal tract reacts to extensive resection with spontaneous intestinal adaptation. We analyzed whether gene expression analyses or intestinal permeability (IP) testing could provide biomarkers to describe regulation mechanisms in the intestinal barrier in short bowel syndrome (SBS) patients during adaptive response or treatment with the glucagon-like peptide-2 analog teduglutide.
Methods: Relevant regions of the GLP-2 receptor gene were sequenced. Gene expression analyses and immunohistochemistry were performed from mucosal biopsies. IP was assessed using a carbohydrate oral ingestion test.
Results: The study includes 59 SBS patients and 19 controls. Increases in gene expression with teduglutide were received for sucrase-isomaltase, sodium/glucose cotransporter 1, and calcium/calmodulin serine protein kinase. Mannitol recovery was decreased in SBS but elevated with teduglutide (Δ 40%), showed a positive correlation with remnant small bowel and an inverse correlation with parenteral support.
Conclusions: Biomarkers predicting clinical and functional features in human SBS are very limited. Altered specific gene expression was shown for genes involved in nutrient transport but not for genes controlling tight junctions. However, mannitol recovery proved useful in describing the absorptive capacity of the gut during adaptation and treatment with teduglutide.

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IIR-DE-002562 Shire Investigator Initiated Research Program; ID 130208 Zealand Company Denmark; 22/81547 Forschungsförderung of the Charité

Keywords: chronic intestinal failure; glucagon-like peptide-2; intestinal permeability; short bowel syndrome; teduglutide

7M19191IKG (teduglutide)
0 (Glucagon-Like Peptide 2)
0 (Biomarkers)
3OWL53L36A (Mannitol)
0 (Gastrointestinal Agents)

Date Created: 20231014 Date Completed: 20231023 Latest Revision: 20231023

20231215

PMC10574292

10.3390/nu15194220

37836505