Burden and predictors of diabetic kidney disease in an adult Ugandan population with new-onset diabetes.

Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE

Original Publication: London : Biomed Central, 2008.

Diabetic Nephropathies*/diagnosis ; Diabetic Nephropathies*/epidemiology ; Diabetes Mellitus, Type 2*/complications ; Hypertension*/complications; Humans ; Adult ; Middle Aged ; Uganda/epidemiology ; Albuminuria/urine ; Glomerular Filtration Rate

Background: Despite the growing evidence of diabetic kidney disease (DKD) in adult patients with long-standing diabetes in sub-Saharan Africa, data on its burden and correlates in adult African patients with new-onset diabetes are limited. We, therefore, undertook this study to determine the burden and predictors of DKD in an adult population with new-onset diabetes in Uganda.
Methods: We collected data on the relevant sociodemographic, clinical, anthropometric, and metabolic characteristics in 519 participants with newly diagnosed diabetes recruited from seven tertiary hospitals. A spot mid-stream urine sample was collected for determination of the urine albumin creatinine ratio (UACR) using Clinitek® microalbumin strips and a point-of-care Clinitek® status analyser. The estimated glomerular filtration rate (e-GFR) was determined using the Chronic Kidney Disease Epidemiology formula. The presence of DKD was defined as a spot UACR ≥ 3 mg/mmol with or without an e-GFR < 60 ml/min/1.73m ² .
Results: The median (IQR) age, UACR, and e-GFR of the participants were 48 years (39-57), 2.27 mg/mmol (1.14-3.41), and 121.8 ml/min/1.73m ² (105.4-133.9). UACR ≥ 3 mg/mmol and e-GFR < 60 ml/min/1.73m ² was noted in 175 (33.7%) and 7 (1.4%) participants, respectively. DKD was documented in 175 participants (33.7%). Compared with those without DKD, participants with DKD were more likely to be ≥ 50 years of age (53.7% vs. 43%, p = 0.02) and to have co-existing hypertension at the time of diagnosis (40.6% vs. 30.1%, p = 0.02). On multivariate analysis, self-reported hypertension comorbidity (OR 1.76 95% CI 1.24-2.48, p = 0.002) and body mass index (BMI) ≥ 30 kg/m ² (OR 0.61 95% CI 0.41-0.91, p = 0.02) were noted to independently predict DKD.
Conclusion: In this study population, DKD was relatively common and was independently associated with self-reported hypertension comorbidity and BMI ≥ 30 kg/m ² .
(© 2023. BioMed Central Ltd., part of Springer Nature.)

Obes Facts. 2021;14(4):338-345. (PMID: 34148035)
Pan Afr Med J. 2012;11:67. (PMID: 22655101)
Hypertens Res. 2011 Apr;34(4):413-22. (PMID: 21228783)
Adv Chronic Kidney Dis. 2011 Jan;18(1):28-41. (PMID: 21224028)
BMC Nephrol. 2017 Apr 3;18(1):116. (PMID: 28372551)
BMC Res Notes. 2018 Aug 06;11(1):565. (PMID: 30081966)
World J Diabetes. 2015 Jun 10;6(5):759-73. (PMID: 26069725)
BMJ Open. 2018 Jan 10;8(1):e015069. (PMID: 29326180)
Kidney Int. 2020 Oct;98(4S):S1-S115. (PMID: 32998798)
Lancet Glob Health. 2014 Mar;2(3):e174-81. (PMID: 25102850)
Diabetes. 2006 Jun;55(6):1832-9. (PMID: 16731850)
S Afr Med J. 2002 Jul;92(7):536-41. (PMID: 12197196)
Diabetes Care. 2007 Aug;30(8):2019-24. (PMID: 17488949)
Anat Rec (Hoboken). 2020 Oct;303(10):2613-2631. (PMID: 31587509)
Kidney Dis (Basel). 2020 Jul;6(4):215-225. (PMID: 32903946)
Wellcome Open Res. 2018 Nov 19;3:149. (PMID: 31223661)
BMJ Open Diabetes Res Care. 2020 Mar;8(1):. (PMID: 32205326)
Public Health Rev. 2021 Apr 09;42:1603969. (PMID: 34692175)
Kidney Int Suppl (2011). 2018 Jan;8(1):2-7. (PMID: 30675433)
J Hypertens. 2011 Sep;29(9):1802-9. (PMID: 21738053)

MC_UP_1204/16 United Kingdom MRC_ Medical Research Council; MC_UP_1204/16 UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement; 17/63/131 National Institute for Health Research (NIHR) Global Health Research Grant

Keywords: Adult patients; Diabetic kidney disease; New-onset diabetes; Sub-saharan Africa; Uganda

Date Created: 20230928 Date Completed: 20231005 Latest Revision: 20250104

20250114

PMC10540316

10.1186/s13104-023-06500-1

37770935