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Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia.

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  • معلومة اضافية
    • المصدر:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8709065 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-226X (Electronic) Linking ISSN: 0284186X NLM ISO Abbreviation: Acta Oncol Subsets: MEDLINE
    • بيانات النشر:
      Publication: London : Informa Healthcare
      Original Publication: Stockholm, Sweden : Acta Oncologica, [1987-
    • الموضوع:
      Precursor Cell Lymphoblastic Leukemia-Lymphoma*/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma*/diagnosis ; Obesity, Morbid*; Humans ; Young Adult ; Body Mass Index ; Retrospective Studies ; Recurrence ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Treatment Outcome
    • نبذة مختصرة :
      Background: Data on outcome for patients in different body mass index (BMI) categories in young adults with acute lymphoblastic leukemia (ALL) are scarce. We explored survival and toxicities in different BMI categories in young adults with ALL.
      Material and Methods: Patients aged 18-45 years, diagnosed with ALL between July 2008 and June 2022 in the Nordic countries, Estonia, or Lithuania, and treated according to the NOPHO ALL2008 protocol, were retrospectively enrolled and classified into different BMI categories. Endpoints were overall survival (OS), event-free survival (EFS) and cumulative incidence of relapse as well as incidence rate ratio (IRR) of severe predefined toxic events, and treatment delays.
      Results: The group comprised 416 patients, of whom 234 (56%) were stratified to non-high-risk (non-HR) treatment. In the non-HR group, patients with severe obesity, BMI ≥35 kg/m 2 had worse EFS due to relapses but there was no effect on toxicity or treatment delays compared with the healthy-weight patients. There was no association between BMI category and OS, overall toxicity, or treatment delays in the patients with high-risk treatment.
      Conclusion: Severe obesity is associated with worse EFS in young adults treated according to the non-HR arms of the NOPHO ALL2008 protocol. Poorer outcome is explained with a higher risk of relapse, possibly due to under treatment, and not caused by excess therapy-related mortality.
    • Contributed Indexing:
      Keywords: Obesity; acute lymphoblastic leukemia; body mass index; toxicity; young adults
    • الموضوع:
      Date Created: 20230919 Date Completed: 20231127 Latest Revision: 20231127
    • الموضوع:
      20231127
    • الرقم المعرف:
      10.1080/0284186X.2023.2258450
    • الرقم المعرف:
      37725524