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Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy.
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- المؤلفون: Hjell G;Hjell G;Hjell G; Rokicki J; Rokicki J; Rokicki J; Szabo A; Szabo A; Szabo A; Holst R; Holst R; Holst R; Tesli N; Tesli N; Bell C; Bell C; Fischer-Vieler T; Fischer-Vieler T; Werner MCF; Werner MCF; Lunding SH; Lunding SH; Ormerod MBEG; Ormerod MBEG; Johansen IT; Johansen IT; Djurovic S; Djurovic S; Djurovic S; Ueland T; Ueland T; Ueland T; Ueland T; Andreassen OA; Andreassen OA; Melle I; Melle I; Lagerberg TV; Lagerberg TV; Mørch-Johnsen L; Mørch-Johnsen L; Mørch-Johnsen L; Steen NE; Steen NE; Haukvik UK; Haukvik UK; Haukvik UK; Haukvik UK
- المصدر:
BMC psychiatry [BMC Psychiatry] 2023 Sep 07; Vol. 23 (1), pp. 659. Date of Electronic Publication: 2023 Sep 07.- نوع النشر :
Journal Article; Research Support, Non-U.S. Gov't- اللغة:
English - المصدر:
- معلومة اضافية
- المصدر: Publisher: BioMed Central Country of Publication: England NLM ID: 100968559 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-244X (Electronic) Linking ISSN: 1471244X NLM ISO Abbreviation: BMC Psychiatry Subsets: MEDLINE
- بيانات النشر: Original Publication: London : BioMed Central, [2001-
- الموضوع:
- نبذة مختصرة : Background: Impulsivity is a transdiagnostic feature linked to severe clinical expression and a potential target for psychopharmacological strategies. Biological underpinnings are largely unknown, but involvement of immune dysregulation has been indicated, and the effects of psychopharmacological agents vary. We investigated if impulsivity was associated with circulating immune marker levels and with a range of psychopharmacological treatment regimens in severe mental disorders.
Methods: Impulsivity was assessed in a sample (N = 657) of patients with schizophrenia or schizophreniform disorder (SCZ) (N = 116) or bipolar disorder (BD) (N = 159) and healthy participants (N = 382) using the Barratt Impulsiveness Scale (BIS-11) questionnaire. Plasma levels of systemic immune markers (RANTES, IL-1RA, IL-18, IL-18BP, sTNFR-1) were measured by enzyme immunoassays. Patients underwent thorough clinical assessment, including evaluation of psychotropic medication. Associations were assessed using linear regressions.
Results: Impulsivity was positively associated with SCZ (p < 0.001) and BD (p < 0.001) diagnosis and negatively associated with age (p < 0.05), but not significantly associated with any of the circulating immune markers independently of diagnostic status. Among patients, impulsivity was negatively associated with lithium treatment (p = 0.003) and positively associated with antidepressant treatment (p = 0.011) after controlling for diagnosis, psychotropic co-medications, manic symptoms, and depressive symptoms.
Conclusions: We report elevated impulsivity across SCZ and BD but no associations to systemic immune dysregulation based on the current immune marker selection. The present study reveals associations between impulsivity in severe mental disorders and treatment with lithium and antidepressants, with opposite directions. Future studies are warranted to determine the causal directionality of the observed associations with psychopharmacotherapy.
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Möller HJ, Schmitt A, Falkai P. Neuroscience-based nomenclature (jNbN) to replace traditional terminology of psychotropic medications. Eur Arch Psychiatry Clin Neurosci. 2016;266(5):385–6. - Contributed Indexing: Keywords: Antidepressants; Bipolar disorder; Chemokine CCL5; Cytokines; Impulsiveness; Interleukin-1; Lithium; Psychopharmacology; Schizophrenia; Tumor necrosis factor
- الرقم المعرف: 9FN79X2M3F (Lithium)
- الموضوع: Date Created: 20230906 Date Completed: 20230908 Latest Revision: 20231122
- الموضوع: 20240628
- الرقم المعرف: PMC10483855
- الرقم المعرف: 10.1186/s12888-023-05154-4
- الرقم المعرف: 37674162
- المصدر:
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