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Modulation of the activation of endothelial nitric oxide synthase and nitrosative stress biomarkers by aspirin triggered lipoxins: A possible mechanism of action of aspirin in the antiphospholipid syndrome.
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- المؤلفون: Granada-Gómez M;Granada-Gómez M; Velásquez-Berrío M; Velásquez-Berrío M; Molina CR; Molina CR; Martín SS; Martín SS; Martín SS; Escudero C; Escudero C; Escudero C; Escudero C; Alvarez AM; Alvarez AM; Cadavid AP; Cadavid AP; Cadavid AP; Cadavid AP
- المصدر:
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2023 Aug; Vol. 90 (2), pp. e13753.- نوع النشر :
Journal Article; Research Support, Non-U.S. Gov't- اللغة:
English - المصدر:
- معلومة اضافية
- المصدر: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 8912860 Publication Model: Print Cited Medium: Internet ISSN: 1600-0897 (Electronic) Linking ISSN: 10467408 NLM ISO Abbreviation: Am J Reprod Immunol Subsets: MEDLINE
- بيانات النشر: Publication: Copenhagen : Wiley-Blackwell
Original Publication: New York : Alan R. Liss, Inc., c1989- - الموضوع:
- نبذة مختصرة : Problem: Antiphospholipid syndrome (APS) is characterized by the clinical manifestation of vascular thrombosis (VT) or pregnancy morbidity (PM) and antiphospholipid antibodies (aPL) that can modify the nitric oxide production. Low-dose aspirin is used in the prevention and treatment of diverse alterations of pregnancy. One of the mechanisms of action of aspirin is to induce the production of aspirin-triggered-lipoxins (ATL). The aim of this study was to evaluate the modulatory effect of ATL over the activation of endothelial nitric oxide synthase (eNOS) and nitrosative stress biomarkers induced by aPL.
Methods: We used polyclonal IgG and sera from women with aPL and PM/VT or VT only, and from women with PM only and positive for non-criteria aPL (SN-OAPS). In these sera, biomarkers of nitrosative stress (nitrites and nitrotyrosine) were measured. The protein expression of nitrotyrosine and the phosphorylation of eNOS (at Ser1177) were estimated in human umbilical vein endothelial cells (HUVECs) stimulated with polyclonal IgG with or without ATL.
Results: Women with SN-OAPS showed increased circulating levels of nitrites and nitrotyrosine. Likewise, polyclonal IgG from either SN-OAPS or VT patients stimulated nitrotyrosine expression in HUVECs. ATL decreased the nitrotyrosine expression induced by polyclonal IgG from the SN-OAPS group. ATL also recovered the reduced eNOS phosphorylation at Ser1177 in HUVECs stimulated with polyclonal IgG from women with PM/VT or SN-OAPS.
Conclusions: Increased nitrosative stress present in serum of women with SN-OAPS is associated with IgG-mediated impaired endothelial NO synthesis in endothelial cells. ATL prevent these cellular changes.
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- الرقم المعرف: R16CO5Y76E (Aspirin)
0 (Lipoxins)
EC 1.14.13.39 (Nitric Oxide Synthase Type III)
0 (Nitrites)
0 (Immunoglobulin G) - الموضوع: Date Created: 20230726 Date Completed: 20230727 Latest Revision: 20230727
- الموضوع: 20230727
- الرقم المعرف: 10.1111/aji.13753
- الرقم المعرف: 37491919
- المصدر:
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