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25OHVitamin D Levels in a Canarian Pediatric Population with and without Type 1 Diabetes: The Role of Acidosis.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: Basel, Switzerland : MDPI Publishing
    • الموضوع:
      Diabetes Mellitus, Type 1*/epidemiology ; Vitamin D Deficiency*/complications ; Vitamin D Deficiency*/epidemiology ; Acidosis*; Humans ; Child ; Retrospective Studies ; Case-Control Studies ; Vitamin D
    • نبذة مختصرة :
      The role of Vitamin D in the development of type 1 diabetes (T1D) is controversial. The Canary Islands have the highest incidence of childhood-onset T1D in Spain and one of the highest in Europe. We aimed to evaluate 25OHVitamin D concentrations in a Canarian pediatric population, to assess the existence of seasonal variation, to study their association with T1D, and to evaluate the role of acidosis in its levels. In a retrospective, case-control study, we obtained data from 146 T1D patients (<15 years of age) and 346 control children; 25OHVitamin D concentrations were assessed in serum by automatic ChemiLuminescence ImmunoAssay technology. We found significantly higher 25OHVitamin D levels in the summer and autumn months and an inverse correlation between T1D and age; 25OHVitamin D sufficiency was similar in both groups (44.5% vs. 45.1%), with significant differences in the percentage of patients presenting vitamin D deficiency (11.6% (T1D) vs. 16.4% (controls)). When stratified according to the presence of ketoacidosis at sampling, only patients with acidosis showed lower 25OHVitamin D concentrations than controls. Despite its subtropical geographic location, Vitamin D deficiency is frequent in children in Gran Canaria, and 25OHVitamin D concentrations show seasonal variation. After adjusting for acidosis, no differences were found between children with and without T1D.
    • References:
      Lancet Infect Dis. 2021 May;21(5):617-628. (PMID: 33476567)
      Clin Rev Allergy Immunol. 2017 Apr;52(2):273-286. (PMID: 27878451)
      Front Immunol. 2021 Oct 01;12:737964. (PMID: 34659229)
      Nutrients. 2022 Apr 29;14(9):. (PMID: 35565821)
      Autoimmunity. 2005 Sep;38(6):439-44. (PMID: 16278149)
      Mol Biol Evol. 2018 Dec 1;35(12):3010-3026. (PMID: 30289472)
      Diabet Med. 2013 Jul;30(7):829-34. (PMID: 23692346)
      Int J Food Sci Nutr. 2009;60 Suppl 5:60-70. (PMID: 18946796)
      Pediatr Diabetes. 2013 Feb;14(1):31-41. (PMID: 22913562)
      J Clin Endocrinol Metab. 2016 Feb;101(2):394-415. (PMID: 26745253)
      PLoS One. 2016 Sep 08;11(9):e0162554. (PMID: 27607348)
      Lancet. 2001 Nov 3;358(9292):1500-3. (PMID: 11705562)
      Ann Pediatr Endocrinol Metab. 2021 Jun;26(2):92-98. (PMID: 33412749)
      Pediatr Diabetes. 2009 Feb;10(1):38-43. (PMID: 18761649)
      Eur J Pediatr. 2015 May;174(5):565-76. (PMID: 25833762)
      J Pediatr. 2009 Jan;154(1):132-4. (PMID: 19187735)
      Am J Clin Nutr. 2003 Dec;78(6):1128-34. (PMID: 14668274)
      Diabetes Care. 2009 Nov;32(11):1977-9. (PMID: 19675194)
      Diabetes. 2018 Jan;67(1):146-154. (PMID: 29061729)
      J Nutr. 2015 Apr;145(4):791-8. (PMID: 25833782)
      Front Endocrinol (Lausanne). 2022 Oct 20;13:997631. (PMID: 36339444)
      Pediatr Diabetes. 2016 Dec;17(8):592-598. (PMID: 26694737)
      Med Clin (Barc). 2004 Sep 11;123(8):286-90. (PMID: 15373974)
      Nutrients. 2010 Apr;2(4):408-25. (PMID: 22254030)
      Front Pediatr. 2022 Oct 05;10:965296. (PMID: 36275052)
      Syst Rev. 2020 Jun 16;9(1):144. (PMID: 32546259)
      Eur J Clin Nutr. 2013 Mar;67(3):270-4. (PMID: 23388663)
      J Pediatr Endocrinol Metab. 2020 Mar 26;33(3):323-330. (PMID: 27760014)
      Nutrients. 2019 Sep 11;11(9):. (PMID: 31514368)
      Front Endocrinol (Lausanne). 2019 Mar 01;10:103. (PMID: 30881343)
      Rev Diabet Stud. 2017 Summer-Fall;14(2-3):260-268. (PMID: 29145536)
      Pediatr Endocrinol Diabetes Metab. 2018;2018(3):111-117. (PMID: 30786675)
      J Pediatr Endocrinol Metab. 2022 Jul 18;35(8):973-988. (PMID: 35850934)
      Curr Diab Rep. 2019 Nov 4;19(11):116. (PMID: 31686270)
    • Grant Information:
      OA1/129 Fundación Mapfre Guanarteme
    • Contributed Indexing:
      Keywords: 25OHVitamin D; acidosis; pediatrics; type 1 diabetes
    • الرقم المعرف:
      1406-16-2 (Vitamin D)
    • الموضوع:
      Date Created: 20230714 Date Completed: 20230717 Latest Revision: 20230718
    • الموضوع:
      20231215
    • الرقم المعرف:
      PMC10346717
    • الرقم المعرف:
      10.3390/nu15133067
    • الرقم المعرف:
      37447392