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Control of histone demethylation by nuclear-localized α-ketoglutarate dehydrogenase.

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  • معلومة اضافية
    • المصدر:
      Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
    • بيانات النشر:
      Publication: : Washington, DC : American Association for the Advancement of Science
      Original Publication: New York, N.Y. : [s.n.] 1880-
    • الموضوع:
      Arabidopsis*/enzymology ; Arabidopsis*/genetics ; Arabidopsis Proteins*/genetics ; Arabidopsis Proteins*/metabolism ; Histones*/metabolism ; Jumonji Domain-Containing Histone Demethylases*/genetics ; Ketoglutarate Dehydrogenase Complex*/genetics ; Ketoglutarate Dehydrogenase Complex*/metabolism; Cell Nucleus/enzymology ; Chromatin/metabolism ; Demethylation ; Histone Demethylases/genetics ; Gene Expression Regulation, Plant
    • نبذة مختصرة :
      Methylations on nucleosomal histones play fundamental roles in regulating eukaryotic transcription. Jumonji C domain-containing histone demethylases (JMJs) dynamically control the level of histone methylations. However, how JMJ activity is generally regulated is unknown. We found that the tricarboxylic acid cycle-associated enzyme α-ketoglutarate (α-KG) dehydrogenase (KGDH) entered the nucleus, where it interacted with various JMJs to regulate α-KG-dependent histone demethylations by JMJs, and thus controlled genome-wide gene expression in plants. We show that nuclear targeting is regulated by environmental signals and that KGDH is enriched at thousands of loci in Arabidopsis thaliana . Chromatin-bound KGDH catalyzes α-KG decarboxylation and thus may limit its local availability to KGDH-coupled JMJs, inhibiting histone demethylation. Thus, our results uncover a regulatory mechanism for histone demethylations by JMJs.
    • الرقم المعرف:
      0 (Arabidopsis Proteins)
      0 (Chromatin)
      EC 1.14.11.- (Histone Demethylases)
      0 (Histones)
      EC 1.14.11.- (Jumonji Domain-Containing Histone Demethylases)
      EC 1.2.4.2 (Ketoglutarate Dehydrogenase Complex)
    • الموضوع:
      Date Created: 20230713 Date Completed: 20230719 Latest Revision: 20231122
    • الموضوع:
      20250114
    • الرقم المعرف:
      10.1126/science.adf8822
    • الرقم المعرف:
      37440635