Species Differences in Platelet Protease-Activated Receptors.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Receptors, Proteinase-Activated*/metabolism ; Receptors, Thrombin*/metabolism; Humans ; Mice ; Animals ; Species Specificity ; Blood Platelets/metabolism ; Thrombin/metabolism

Protease-activated receptors (PARs) are a class of integral membrane proteins that are cleaved by a variety of proteases, most notably thrombin, to reveal a tethered ligand and promote activation. PARs are critical mediators of platelet function in hemostasis and thrombosis, and therefore are attractive targets for anti-platelet therapies. Animal models studying platelet PAR physiology have relied heavily on genetically modified mouse strains, which have provided ample insight but have some inherent limitations. The current review aims to summarize the notable PAR expression and functional differences between the mouse and human, in addition to highlighting some recently developed tools to further study human physiology in mouse models.

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Keywords: BMS-986120; antiplatelet agents; protease-activated receptor 4 (PAR4)

0 (Receptors, Proteinase-Activated)
0 (Receptors, Thrombin)
EC 3.4.21.5 (Thrombin)

Date Created: 20230513 Date Completed: 20230515 Latest Revision: 20230515

20230515

PMC10179473

10.3390/ijms24098298

37176005