The Effects of Wildfire Smoke on Asthma and Allergy.

Publisher: Current Science Inc Country of Publication: United States NLM ID: 101096440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-6315 (Electronic) Linking ISSN: 15297322 NLM ISO Abbreviation: Curr Allergy Asthma Rep Subsets: MEDLINE

Original Publication: Philadelphia, PA : Current Science Inc., c2001-

Wildfires* ; Asthma*/etiology ; Air Pollutants*/adverse effects; Animals ; Humans ; Smoke/adverse effects ; Environmental Exposure/adverse effects ; Nose/chemistry ; Particulate Matter/adverse effects

Purpose of Review: To review the recent literature on the effects of wildfire smoke (WFS) exposure on asthma and allergic disease, and on potential mechanisms of disease.
Recent Findings: Spatiotemporal modeling and increased ground-level monitoring data are allowing a more detailed picture of the health effects of WFS exposure to emerge, especially with regard to asthma. There is also epidemiologic and some experimental evidence to suggest that WFS exposure increases allergic predisposition and upper airway or sinonasal disease, though much of the literature in this area is focused more generally on PM 2.5 and is not specific for WFS. Experimental evidence for mechanisms includes disruption of epithelial integrity with downstream effects on inflammatory or immune pathways, but experimental models to date have not consistently reflected human disease in this area. Exposure to WFS has an acute detrimental effect on asthma. Potential mechanisms are suggested by in vitro and animal studies.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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P30 ES010126 United States ES NIEHS NIH HHS; K01 ES032837 United States ES NIEHS NIH HHS; T32 DC005360 United States DC NIDCD NIH HHS

Keywords: Allergy; Asthma; Wildfire smoke; Wood smoke

0 (Smoke)
0 (Particulate Matter)
0 (Air Pollutants)

Date Created: 20230512 Date Completed: 20230721 Latest Revision: 20240918

20240918

PMC10176314

10.1007/s11882-023-01090-1

37171670