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Analysis of patients with colorectal cancer shows a specific increase in serum anti-ING1 autoantibody levels.

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اقرأ أكثر
  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2001-
    • الموضوع:
      Tumor Suppressor Proteins*/genetics ; Tumor Suppressor Proteins*/metabolism ; Colorectal Neoplasms*/diagnosis; Humans ; Inhibitor of Growth Protein 1/metabolism ; Tumor Suppressor Protein p53/metabolism ; Nuclear Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Autoantibodies
    • نبذة مختصرة :
      Colorectal cancer (CRC) is the third most prevalent cancer in the world, yet the sensitivity and specificity of biomarkers for CRC diagnosis are insufficient. In the present study, we performed a protein microarray screening method to identify antibody markers for CRC. Inhibitor of growth family 1 (ING1) was identified as a candidate tumor antigen for CRC using protein microarrays (ProtoArray). Subsequent amplified luminescence proximity homogeneous assay-linked immunosorbent assay using recombinant ING1 protein showed that the serum levels of anti-ING1 antibodies were increased not only in patients with CRC but also in those with esophageal cancer (EC), gastric cancer (GC), breast cancer (BrC), and pancreatic cancer (PC) compared with those of healthy donors (HDs). Antibodies against the ING1 amino acids between 239 and 253 were present at significantly higher levels in patients with CRC than in those with EC, GC, BrC, or PC. Anti-ING1 antibody levels were significantly higher in the patients with CRC at any stages than in the HDs. Immunohistochemical staining revealed higher expression of ING1 protein in CRC cells than in the adjacent normal tissues. In luciferase reporter assays using a CRC cell line, ING1 augmented p53-mediated NOXA promoter activity but attenuated p53-stimulated Bax, p21, and PUMA promoter activities. Consequently, serum anti-ING1 antibodies can be used for sensitive and specific diagnoses of CRC.
      (© 2023. The Author(s).)
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    • Contributed Indexing:
      Keywords: Antibody; Colorectal cancer; Inhibitor of growth protein 1; Protein array analysis; Tumor biomarker
    • الرقم المعرف:
      0 (Inhibitor of Growth Protein 1)
      0 (Tumor Suppressor Proteins)
      0 (Tumor Suppressor Protein p53)
      0 (Nuclear Proteins)
      0 (Intracellular Signaling Peptides and Proteins)
      0 (Autoantibodies)
    • الموضوع:
      Date Created: 20230418 Date Completed: 20230420 Latest Revision: 20230519
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC10111810
    • الرقم المعرف:
      10.1186/s12885-023-10845-y
    • الرقم المعرف:
      37072777