Swept-Source OCT Mid-Peripheral Retinal Irregularity in Retinal Detachment and Posterior Vitreous Detachment Eyes.

Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101676056 Publication Model: Electronic Cited Medium: Print ISSN: 2306-5354 (Print) Linking ISSN: 23065354 NLM ISO Abbreviation: Bioengineering (Basel) Subsets: PubMed not MEDLINE

Original Publication: Basel, Switzerland : MDPI AG, [2014]-

Irregularities in retinal shape have been shown to correlate with axial length, a major risk factor for retinal detachment. To further investigate this association, a comparison was performed of the swept-source optical coherence tomography (SS OCT) peripheral retinal shape of eyes that had either a posterior vitreous detachment (PVD) or vitrectomy for retinal detachment. The objective was to identify a biomarker that can be tested as a predictor for retinal detachment. Eyes with a PVD (N = 88), treated retinal detachment (N = 67), or retinal tear (N = 53) were recruited between July 2020 and January 2022 from hospital retinal clinics in South Australia. The mid-peripheral retina was imaged in four quadrants with SS OCT. The features explored were patient age, eye axial length, and retinal shape irregularity quantified in the frequency domain. A discriminant analysis classifier to identify retinal detachment eyes was trained with two-thirds and tested with one-third of the sample. Retinal detachment eyes had greater irregularity than PVD eyes. A classifier trained using shape features from the superior and temporal retina had a specificity of 84% and a sensitivity of 48%. Models incorporating axial length were less successful, suggesting peripheral retinal irregularity is a better biomarker for retinal detachment than axial length. Mid-peripheral retinal irregularity can identify eyes that have experienced a retinal detachment.

Ophthalmology. 2023 Feb 10;:. (PMID: 36773761)
J Biomed Opt. 2019 Jun;24(6):1-10. (PMID: 31254332)
Am J Ophthalmol. 2014 Jun;157(6):1272-1281.e1. (PMID: 24561169)
Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3380-6. (PMID: 15452039)
Opt Express. 2009 Mar 2;17(5):3978-9. (PMID: 19259239)
JAMA Ophthalmol. 2021 Aug 01;139(8):857-864. (PMID: 34165493)
Phys Med Biol. 2013 May 7;58(9):2925-38. (PMID: 23574790)
Clin Ophthalmol. 2022 Dec 23;16:4315-4321. (PMID: 36583093)
Am J Ophthalmol. 2015 Sep;160(3):596-601.e1. (PMID: 26045044)
PLoS One. 2019 Dec 30;14(12):e0227207. (PMID: 31887186)
Jpn J Ophthalmol. 2020 Mar;64(2):180-186. (PMID: 32040660)
Opt Express. 2011 Feb 14;19(4):3044-62. (PMID: 21369128)
Sci Rep. 2017 Aug 31;7(1):10155. (PMID: 28860560)
Am J Ophthalmol. 2013 Nov;156(5):958-967.e1. (PMID: 23972305)
Hum Mol Genet. 2020 Mar 13;29(4):689-702. (PMID: 31816047)
Ophthalmology. 2014 Jan;121(1):246-250. (PMID: 24095605)
Am J Ophthalmol. 2008 May;145(5):909-14. (PMID: 18342827)
Ophthalmology. 2014 Aug;121(8):1588-97. (PMID: 24793526)
Taiwan J Ophthalmol. 2016 Apr-Jun;6(2):58-68. (PMID: 29018713)
Biomed Opt Express. 2014 Sep 12;5(10):3568-77. (PMID: 25360373)
Retina. 2017 Aug;37(8):1428-1440. (PMID: 28085774)
Retina. 2016 May;36(5):962-6. (PMID: 27115858)
Ophthalmic Genet. 2016 Jun;37(2):121-9. (PMID: 26757352)
Cochrane Database Syst Rev. 2001;(3):CD003170. (PMID: 11687045)
PLoS One. 2012;7(6):e39300. (PMID: 22723992)
Retina. 2020 Jun;40(6):1094-1097. (PMID: 30865062)
Br J Ophthalmol. 2012 Jan;96(1):110-3. (PMID: 21378003)
Acta Ophthalmol (Copenh). 1987 Apr;65(2):213-22. (PMID: 3604613)
Am J Ophthalmol. 2013 Aug;156(2):304-11. (PMID: 23659972)
Retina. 2023 Jan 1;43(1):88-93. (PMID: 36165842)
Transl Vis Sci Technol. 2022 Aug 1;11(8):11. (PMID: 35972433)
Opt Express. 2003 Sep 8;11(18):2183-9. (PMID: 19466106)
Asia Pac J Ophthalmol (Phila). 2019 Sep-Oct;8(5):355-359. (PMID: 31425168)
Graefes Arch Clin Exp Ophthalmol. 2016 Nov;254(11):2119-2129. (PMID: 27106626)
Asia Pac J Ophthalmol (Phila). 2019 Mar 29;:. (PMID: 30924327)
Prog Retin Eye Res. 2022 Dec 28;:101156. (PMID: 36585290)
Ophthalmology. 2003 Jun;110(6):1175-7. (PMID: 12799244)
Ophthalmic Surg Lasers Imaging Retina. 2022 Jan;53(1):7-11. (PMID: 34982001)
Medicine (Baltimore). 2019 Jan;98(4):e14225. (PMID: 30681601)
Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3750-3758. (PMID: 28738419)
Aust J Ophthalmol. 1980 Nov;8(4):275-9. (PMID: 7224982)
Ophthalmology. 2013 Mar;120(3):616-622. (PMID: 23218185)
Trans Am Ophthalmol Soc. 1989;87:143-55; discussion 155-7. (PMID: 2562517)
Am J Ophthalmol. 2019 Apr;200:110-122. (PMID: 30639367)
Ophthalmol Ther. 2023 Feb;12(1):155-165. (PMID: 36271185)

Keywords: Fourier analysis; machine learning; optical coherence tomography; posterior vitreous detachment; retinal detachment

Date Created: 20230329 Latest Revision: 20230331

20231215

PMC10044997

10.3390/bioengineering10030377

36978768