Use test with l-carvone in toothpaste on sensitized individuals.

Publisher: Wiley Country of Publication: England NLM ID: 7604950 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0536 (Electronic) Linking ISSN: 01051873 NLM ISO Abbreviation: Contact Dermatitis Subsets: MEDLINE

Publication: <2005-> : Oxford : Wiley
Original Publication: Copenhagen, Munksgaard.

Dermatitis, Allergic Contact*/diagnosis ; Dermatitis, Allergic Contact*/etiology ; Lichen Planus, Oral*/diagnosis ; Eczema*; Humans ; Toothpastes/adverse effects ; Quality of Life

Background: The mint flavour carvone (l-carvone) is considered a weak contact allergen. However, contact allergy to carvone is more prevalent in patients with oral lichen planus or oral lichenoid lesions (OLP/OLL).
Objective: Our aim was to investigate how carvone affects sensitized individuals through a use test with toothpaste containing carvone. Non-flavoured toothpaste served as control.
Methods: Subjects were patch tested prior to the use test-14 subjects allergic to carvone (11 with OLP/OLL), 20 subjects with OLP/OLL and 3 healthy controls. The month-long use test comprised of using toothpaste twice daily. Subjects were examined fortnightly. Clinical signs were assessed with a mucosal scoring system. The subjects' oral health-related quality of life was measured with the oral health impact profile (OHIP-49).
Results: Local reactions to the carvone toothpaste presented as aggravated OLL (7/10) and peri-oral eczema (2/10) in allergic subjects. They also had significantly higher mucosal and OHIP scores compared with those receiving non-flavoured toothpaste.
Conclusion: In sensitized individuals, oral exposure to carvone gives aggravated oral lesions and/or peri-oral eczema. The lesions mimic OLP and allergic individuals are therefore at risk of not being assessed with regard to flavour contact allergy.
(© 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.)

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Svenska Tandläkare-Sällskapet

Keywords: OHIP-49; contact cheilitis; contact stomatitis; l-carvone; mucosal score; oral lichen planus; oral lichenoid lesion; toothpaste; use test

75GK9XIA8I (carvone)
0 (Toothpastes)

Date Created: 20230317 Date Completed: 20230508 Latest Revision: 20230508

20240829

10.1111/cod.14302

36929649