Maternal epigenetic factors in embryonic and postnatal development.

Publisher: Blackwell Science Ltd Country of Publication: England NLM ID: 9607379 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2443 (Electronic) Linking ISSN: 13569597 NLM ISO Abbreviation: Genes Cells Subsets: MEDLINE

Original Publication: Oxford, UK : Blackwell Science Ltd., 1996-

Oocytes*/metabolism ; Transcription Factors*/genetics ; Transcription Factors*/metabolism; Pregnancy ; Female ; Animals ; Mice ; Histone Demethylases/genetics ; Histone Demethylases/metabolism ; Epigenesis, Genetic ; Embryonic Development/genetics

Maternal factors present in oocytes and surrounding granulosa cells influence early development of embryos. In this study, we searched for epigenetic regulators that are expressed in oocytes and/or granulosa cells. Some of the 120 epigenetic regulators examined were expressed specifically in oocytes and/or granulosa cells. When their expression was examined in young versus aged oocytes or granulosa cells, many were significantly up- or downregulated in aged cells. The maternal role of six genes in development was investigated by generating oocyte-specific knock-out (MKO) mice. Two genes (Mllt10, Kdm2b) did not show maternal effects on later development, whereas maternal effects were evident for Kdm6a, Kdm4a, Prdm3, and Prdm16 for MKO female mice. Offspring from Kdm6a MKO mice underwent perinatal lethality at a higher rate. Pups derived from Prdm3;Prdm16 double MKO showed a higher incidence of postnatal death. Finally, embryos derived from Kdm4a MKO mice showed early developmental defects as early as the peri-implantation stage. These results suggest that many of maternal epigenetic regulators undergo differential expression upon aging. Some, such as Kdm4a, Kdm6a, Prdm3, and Prdm16, have maternal role in later embryonic or postnatal development.
(© 2023 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd.)

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JPMJCR21N6 Core Research for Evolutional Science and Technology; 17H01435 Ministry of Education, Culture, Sports, Science and Technology; 20H00472 Ministry of Education, Culture, Sports, Science and Technology; RIKEN

Keywords: aging; development; epigenetics; maternal factor

0 (Transcription Factors)
EC 1.14.11.- (Histone Demethylases)

Date Created: 20230312 Date Completed: 20230609 Latest Revision: 20230609

20240829

10.1111/gtc.13024

36906847