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Antioxidant Activity of Polysaccharides from the Edible Mushroom Pleurotus eryngii .
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- معلومة اضافية
- المصدر:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI, c1995-
- الموضوع:
- نبذة مختصرة :
In this study the antioxidant and neuroprotective activity of an enriched polysaccharide fraction (EPF) obtained from the fruiting body of cultivated P. eryngii was evaluated. Proximate composition (moisture, proteins, fat, carbohydrates and ash) was determined using the AOAC procedures. The EPF was extracted by using, in sequence, hot water and alkaline extractions followed by deproteinization and precipitation with cold ethanol. Total α- and β-glucans were quantified using the Megazyme International Kit. The results showed that this procedure allows a high yield of polysaccharides with a higher content of (1-3; 1-6)-β-D-glucans. The antioxidant activity of EPF was detected from the total reducing power, DPPH, superoxide, hydroxyl and nitric oxide radical scavenging activities. The EPF was found to scavenge DPPH, superoxide, hydroxyl and nitric oxide radicals with a IC50 values of 0.52 ± 0.02, 1.15 ± 0.09, 0.89 ± 0.04 and 2.83 ± 0.16 mg/mL, respectively. As assessed by the MTT assay, the EPF was biocompatible for DI-TNC1 cells in the range of 0.006-1 mg/mL and, at concentrations ranging from 0.05 to 0.2 mg/mL, significantly counteracted H 2 O 2 -induced reactive oxygen species production. This study demonstrated that polysaccharides extracted from P. eryngii might be used as functional food to potentiate the antioxidant defenses and to reduce oxidative stress.
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- Grant Information:
CUP G29J21005620006 PSR 2014-2020 Regione Basilicata, Misura 16, Sottomisura 16.2-Sostegno a progetti pilota e allo sviluppo di nuovi prodotti, pratiche, processi e tecnologie. Innovazione tecnologica e di processo per la produzione in continuo di funghi coltivati in biologi
- Contributed Indexing:
Keywords: Pleurotus eryngii; antioxidant activity; mushrooms; neuroprotection; polysaccharides; β-glucan
- الرقم المعرف:
0 (Antioxidants)
11062-77-4 (Superoxides)
31C4KY9ESH (Nitric Oxide)
BBX060AN9V (Hydrogen Peroxide)
0 (Polysaccharides)
3352-57-6 (Hydroxyl Radical)
- الموضوع:
Pleurotus eryngii
- الموضوع:
Date Created: 20230311 Date Completed: 20230314 Latest Revision: 20230314
- الموضوع:
20240628
- الرقم المعرف:
PMC10005153
- الرقم المعرف:
10.3390/molecules28052176
- الرقم المعرف:
36903422
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