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Individual and joint effect of indoor air pollution index and ambient particulate matter on fetal growth: a prospective cohort study.

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اقرأ على الانترنت اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • المصدر:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 7802871 Publication Model: Print Cited Medium: Internet ISSN: 1464-3685 (Electronic) Linking ISSN: 03005771 NLM ISO Abbreviation: Int J Epidemiol Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: [London] Oxford University Press.
    • الموضوع:
      Air Pollutants*/adverse effects ; Air Pollutants*/analysis ; Air Pollution, Indoor*/adverse effects ; Air Pollution*/adverse effects; Female ; Humans ; Pregnancy ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Prospective Studies ; Cohort Studies ; Fetal Development ; China/epidemiology ; Environmental Exposure/adverse effects
    • نبذة مختصرة :
      Background: Limited studies have examined the effect of prenatal exposure to particulate matter with diameter of <2.5 µm (PM2.5) and <1 μm (PM1) on fetal growth using ultrasound measurements with inconsistent results. No study has evaluated the joint effect of the indoor air pollution index and ambient particulate matter on fetal growth.
      Methods: We conducted a prospective birth cohort study in Beijing, China in 2018, including 4319 pregnant women. We estimated prenatal PM2.5 and PM1 exposure using a machine-learning method and calculated the indoor air pollution index based on individual interviews. Gender- and gestational age-adjusted Z-score of the abdominal circumference (AC), head circumference (HC), femur length (FL) and estimated fetal weight (EFW) was calculated and then undergrowth was defined. A generalized estimating equation was used to evaluate the individual and joint effect of indoor air pollution index, PM2.5 and PM1 on fetal Z-score and undergrowth parameters.
      Results: One unit increase in the indoor air pollution index was associated with -0.044 (95% CI: -0.087, -0.001) and -0.050 (95% CI: -0.094, -0.006) decrease in the AC and HC Z-scores, respectively. PM1 and PM2.5 were associated with decreased AC, HC, FL and EFW Z-scores, and higher risk of undergrowth. Compared with exposure to lower PM1 (≤ median) and no indoor air pollution, those exposed to higher PM1 (> median) and indoor air pollution had decreased EFW Z-scores (β = -0.152, 95% CI: -0.230, -0.073) and higher risk of EFW undergrowth (RR = 1.651, 95% CI: 1.106, 2.464). Indoor air pollution and ambient PM2.5 exposure had a similar joint effect on the Z-scores and undergrowth parameters of fetal growth.
      Conclusions: This study suggested that indoor air pollution and ambient PM exposure had individual and joint negative effects on fetal growth.
      (© The Author(s) 2023; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.)
    • Contributed Indexing:
      Keywords: Air pollution; PM1; PM2.5; fetal growth; indoor; prenatal exposure
    • الرقم المعرف:
      0 (Particulate Matter)
      0 (Air Pollutants)
    • الموضوع:
      Date Created: 20230307 Date Completed: 20230608 Latest Revision: 20230608
    • الموضوع:
      20230608
    • الرقم المعرف:
      10.1093/ije/dyad021
    • الرقم المعرف:
      36882118