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Association between toxic metals, vitamin D and preterm birth in the Maternal-Infant research on environmental chemicals study.
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- المؤلفون: Fisher M;Fisher M;Fisher M; Marro L; Marro L; Arbuckle TE; Arbuckle TE; Potter BK; Potter BK; Little J; Little J; Weiler H; Weiler H; Morisset AS; Morisset AS; Lanphear B; Lanphear B; Oulhote Y; Oulhote Y; Braun JM; Braun JM; Kumarathasan P; Kumarathasan P; Walker M; Walker M; Borghese MM; Borghese MM; Ashley-Martin J; Ashley-Martin J; Shutt R; Shutt R; Fraser WD; Fraser WD
- المصدر:
Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2023 Jul; Vol. 37 (5), pp. 447-457. Date of Electronic Publication: 2023 Mar 02.- نوع النشر :
Journal Article; Research Support, Non-U.S. Gov't- اللغة:
English - المصدر:
- معلومة اضافية
- المصدر: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8709766 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-3016 (Electronic) Linking ISSN: 02695022 NLM ISO Abbreviation: Paediatr Perinat Epidemiol Subsets: MEDLINE
- بيانات النشر: Original Publication: Oxford ; Boston : Blackwell Scientific Publications, [c1987-
- الموضوع:
- نبذة مختصرة : Background: Toxic metals, like lead, are risk factors for preterm birth (PTB), but few studies have examined low levels found in most Canadians. Vitamin D, which may have antioxidant activity, protects against PTB.
Objectives: In this study, we investigated the impact of toxic metals (lead, mercury, cadmium and arsenic) on PTB and examined if maternal plasma vitamin D concentrations modify these associations.
Methods: We investigated whether concentrations of metals in whole blood measured in early and late pregnancy were associated with PTB (<37 weeks) and spontaneous PTB in 1851 live births from the Maternal-Infant Research on Environmental Chemicals Study using discrete time survival analysis. We also investigated whether the risk of PTB was modified by first-trimester plasma 25-hydroxyvitamin D (25OHD) concentrations.
Results: Of 1851 live births, 6.1% (n = 113) were PTBs and 4.9% (n = 89) were spontaneous PTB. A 1 μg/dL increase in blood lead concentrations during pregnancy was associated with an increased risk of PTB (relative risk [RR] 1.48, 95% confidence interval [CI] 1.00, 2.20) and spontaneous PTB (RR 1.71, 95% CI 1.13, 2.60). The risk was higher in women with insufficient vitamin D concentrations (25OHD <50 nmol/L) for both PTB (RR 2.42, 95% CI 1.01, 5.79) and spontaneous PTB (RR 3.04, 95% CI 1.15, 8.04). However, an interaction on the additive scale was not present. Arsenic was associated with a higher risk of PTB (RR 1.10, 95% CI 1.02, 1.19) and spontaneous PTB (RR 1.11, 95% CI 1.03, 1.20) per 1 μg/L.
Conclusions: Gestational exposure to low levels of lead and arsenic may increase the risk of PTB and spontaneous PTB; individuals with insufficient vitamin D may be more susceptible to the adverse effects of lead. Given our relatively small number of cases, we encourage testing of this hypothesis in other cohorts, especially those with vitamin D-deficient populations.
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- Contributed Indexing: Keywords: 25-hydroxyvitamin D; arsenic; cadmium; lead; mercury; metals; preterm birth
- الرقم المعرف: N712M78A8G (Arsenic)
2P299V784P (Lead)
1406-16-2 (Vitamin D)
0 (Vitamins) - الموضوع: Date Created: 20230302 Date Completed: 20230717 Latest Revision: 20230718
- الموضوع: 20230718
- الرقم المعرف: 10.1111/ppe.12962
- الرقم المعرف: 36864001
- المصدر:
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