Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics.

Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-

Biopolymers*/biosynthesis ; Brain*/enzymology ; Enzymes*/metabolism ; Peripheral Nervous System*/enzymology ; Electric Conductivity*; Animals ; Electrodes ; Electronics ; Leeches ; Models, Animal ; Polymerization ; Zebrafish

Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo-fabricated electronics within the nervous system.

0 (Biopolymers)
0 (Enzymes)

Date Created: 20230223 Date Completed: 20230323 Latest Revision: 20230323

20231215

10.1126/science.adc9998

36821679