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Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics.
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- معلومة اضافية
- المصدر:
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
- بيانات النشر:
Publication: : Washington, DC : American Association for the Advancement of Science
Original Publication: New York, N.Y. : [s.n.] 1880-
- الموضوع:
- نبذة مختصرة :
Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo-fabricated electronics within the nervous system.
- الرقم المعرف:
0 (Biopolymers)
0 (Enzymes)
- الموضوع:
Date Created: 20230223 Date Completed: 20230323 Latest Revision: 20230323
- الموضوع:
20231215
- الرقم المعرف:
10.1126/science.adc9998
- الرقم المعرف:
36821679
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