Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
Computational design of clinical trials using a combination of simulation and the genetic algorithm.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Processing Request
- المؤلفون: Tsuchiwata S;Tsuchiwata S;Tsuchiwata S; Tsuji Y; Tsuji Y
- المصدر:
CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2023 Apr; Vol. 12 (4), pp. 522-531. Date of Electronic Publication: 2023 Mar 05.
- نوع النشر :
Journal Article
- اللغة:
English
- معلومة اضافية
- المصدر:
Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE
- بيانات النشر:
Publication: 2015- : Hoboken, NJ : Wiley
Original Publication: New York, NY : Nature Pub. Group
- الموضوع:
- نبذة مختصرة :
Artificial intelligence (AI) has come to be used in various technological fields in recent years. However, there have been no reports of AI-designed clinical trials. In this study, we tried to develop study designs by a genetic algorithm (GA), which is an AI solution for combination optimization problems. Specifically, the computational design approach was applied to optimize the blood sampling schedule for a bioequivalence (BE) study in pediatrics and optimize the allocation of dose groups for a dose-finding study. The GA could reduce the number of blood collection points from 15 (typical standard) to seven points without meaningful impact on the accuracy and precision of the pharmacokinetic estimation for the pediatric BE study. For the dose-finding study, up to 10% reduction of the total number of required subjects from the standard design could be achieved. The GA also created a design that would lead to a drastic reduction of the required number of subjects in the placebo arm while keeping the total number of subjects at a minimum level. These results indicated the potential usefulness of the computational clinical study design approach for innovative drug development.
(© 2023 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.)
- References:
Br J Clin Pharmacol. 2022 Feb;88(4):1482-1499. (PMID: 33634893)
Clin Pharmacol Ther. 2021 Jul;110(1):49-63. (PMID: 32936931)
CPT Pharmacometrics Syst Pharmacol. 2023 Apr;12(4):522-531. (PMID: 36793239)
CPT Pharmacometrics Syst Pharmacol. 2019 Jul;8(7):440-443. (PMID: 31006175)
Biometrics. 2005 Sep;61(3):738-48. (PMID: 16135025)
Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):228-34. (PMID: 15733219)
Drug Res (Stuttg). 2017 Aug;67(8):451-457. (PMID: 28561232)
Clin Pharmacol Ther. 2020 Apr;107(4):926-933. (PMID: 31930487)
Int J Mol Sci. 2020 Apr 04;21(7):. (PMID: 32260456)
Brief Bioinform. 2019 Jul 19;20(4):1434-1448. (PMID: 29438494)
Br J Clin Pharmacol. 2019 Sep;85(9):1871-1873. (PMID: 31281980)
J Pharmacokinet Pharmacodyn. 2022 Feb;49(1):65-79. (PMID: 34611796)
J Biopharm Stat. 2000 Feb;10(1):31-44. (PMID: 10709799)
Multimed Tools Appl. 2021;80(5):8091-8126. (PMID: 33162782)
Saudi Pharm J. 2014 Nov;22(5):391-402. (PMID: 25473327)
Prog Biophys Mol Biol. 2018 Nov;139:15-22. (PMID: 29902482)
J Digit Imaging. 2022 Jun;35(3):623-637. (PMID: 35199257)
Comput Methods Programs Biomed. 2016 Apr;127:83-93. (PMID: 27000291)
Anesthesiology. 2020 Jan;132(1):69-81. (PMID: 31809323)
J Pharmacokinet Pharmacodyn. 2022 Apr;49(2):257-270. (PMID: 34708337)
AAPS J. 2017 Dec 28;20(1):24. (PMID: 29285730)
Clin Pharmacol Ther. 2013 Jun;93(6):502-14. (PMID: 23588322)
Stat Med. 2014 May 10;33(10):1646-61. (PMID: 24302486)
J Biopharm Stat. 2020 Jul 3;30(4):662-673. (PMID: 32183578)
Clin Pharmacol Ther. 2020 Jun;107(6):1343-1351. (PMID: 31863460)
J Biopharm Stat. 2006;16(5):639-56. (PMID: 17037263)
J Pharm Pharmacol. 2019 Nov;71(11):1635-1644. (PMID: 31412422)
iScience. 2021 Jun 30;24(7):102804. (PMID: 34308294)
CPT Pharmacometrics Syst Pharmacol. 2021 Oct;10(10):1127-1129. (PMID: 34404115)
Sensors (Basel). 2021 Jan 22;21(3):. (PMID: 33499364)
Clin Pharmacokinet. 2021 Nov;60(11):1435-1448. (PMID: 34041714)
CPT Pharmacometrics Syst Pharmacol. 2021 Jul;10(7):760-768. (PMID: 33955705)
AAPS J. 2021 Apr 21;23(3):57. (PMID: 33884497)
J Pharmacokinet Pharmacodyn. 2021 Aug;48(4):597-609. (PMID: 34019213)
Clin Trials. 2021 Dec;18(6):706-710. (PMID: 34657476)
CPT Pharmacometrics Syst Pharmacol. 2021 Jan;10(1):75-83. (PMID: 33314752)
Stat Med. 2010 Mar 30;29(7-8):731-42. (PMID: 20213708)
Health Inf Sci Syst. 2022 Feb 09;10(1):2. (PMID: 35178244)
- الموضوع:
Date Created: 20230216 Date Completed: 20230412 Latest Revision: 20230420
- الموضوع:
20240628
- الرقم المعرف:
PMC10088085
- الرقم المعرف:
10.1002/psp4.12944
- الرقم المعرف:
36793239
No Comments.