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Natural Agents as Novel Potential Source of Proteasome Inhibitors with Anti-Tumor Activity: Focus on Multiple Myeloma.
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- معلومة اضافية
- المصدر:
Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
- بيانات النشر:
Original Publication: Basel, Switzerland : MDPI, c1995-
- الموضوع:
- نبذة مختصرة :
Multiple myeloma (MM) is an aggressive and incurable disease for most patients, characterized by periods of treatment, remission and relapse. The introduction of new classes of drugs, such as proteasome inhibitors (PIs), has improved survival outcomes in these patient populations. The proteasome is the core of the ubiquitin-proteasome system (UPS), a complex and conserved pathway involved in the control of multiple cellular processes, including cell cycle control, transcription, DNA damage repair, protein quality control and antigen presentation. To date, PIs represent the gold standard for the treatment of MM. Bortezomib was the first PI approved by the FDA, followed by next generation of PIs, namely carfilzomib and ixazomib. Natural agents play an important role in anti-tumor drug discovery, and many of them have recently been reported to inhibit the proteasome, thus representing a new potential source of anti-MM drugs. Based on the pivotal biological role of the proteasome and on PIs' significance in the management of MM, in this review we aim to briefly summarize recent evidence on natural compounds capable of inhibiting the proteasome, thus triggering anti-MM activity.
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- Grant Information:
IG24449 Italian Association for Cancer Research; GR-2016-02361523 Italian Ministry of Health; PRIN 2017 - 201744BN5T Ministry of Education, Universities and Research
- Contributed Indexing:
Keywords: multiple myeloma; natural compounds; proteasome; proteasome inhibitors
- الرقم المعرف:
0 (Proteasome Inhibitors)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
0 (Antineoplastic Agents)
69G8BD63PP (Bortezomib)
- الموضوع:
Date Created: 20230211 Date Completed: 20230214 Latest Revision: 20230214
- الموضوع:
20231215
- الرقم المعرف:
PMC9919276
- الرقم المعرف:
10.3390/molecules28031438
- الرقم المعرف:
36771100
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