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The significance of ophthalmological features in diagnosis of thyroid-associated ophthalmopathy.

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  • معلومة اضافية
    • المصدر:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101147518 Publication Model: Electronic Cited Medium: Internet ISSN: 1475-925X (Electronic) Linking ISSN: 1475925X NLM ISO Abbreviation: Biomed Eng Online Subsets: MEDLINE
    • بيانات النشر:
      Original Publication: London : BioMed Central, [2002-
    • الموضوع:
      Graves Ophthalmopathy*/diagnosis; Male ; Female ; Humans ; Adult ; Middle Aged ; Oculomotor Muscles
    • نبذة مختصرة :
      Background: Thyroid-associated ophthalmopathy (TAO) is an autoimmune disorder. It has discriminable appearance. This study was conducted to dig the clinical significance of demographic characteristics and ophthalmologic diagram features in TAO diagnosis and stage/severity evaluation.
      Results: We included 320 males and 633 females, with an average age of 41.75 ± 13.75. A majority of TAO patients had hyperthyroidism, and most of them were in the inactive stage and at the moderate level. The thyroid function type, stage and severity were closely associated with hypopsia, eyelid congestion, conjunctival congestion, corneal ulcer, ocular motility disorder, best corrected visual acuity, and extraocular muscle thickening. Using these features, we established different logistic regression models to predict thyroid function subtypes, abnormal thyroid function, stage, and severity, in which the AUC of the ROC curve and accuracies were satisfactory.
      Conclusion: Together, TAO subtype, stage and severity can be diagnosed by auxiliary references including demographic factors, symptoms from complains, and image features. These non-invasive indices can be applied in a timely manner in clinical estimating TAO status.
      (© 2023. The Author(s).)
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    • Grant Information:
      81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China; 81800865 Young Science Foundation of National Natural Science Foundation of China
    • Contributed Indexing:
      Keywords: Auxiliary diagnosis; Graves’ ophthalmopathy; Ophthalmic images; Thyroid function; Thyroid-associated ophthalmopathy
    • الموضوع:
      Date Created: 20230204 Date Completed: 20230207 Latest Revision: 20230207
    • الموضوع:
      20250114
    • الرقم المعرف:
      PMC9898900
    • الرقم المعرف:
      10.1186/s12938-023-01073-3
    • الرقم المعرف:
      36739403